動脈硬化における凝固・線溶系(<特集>動脈硬化とアフェレシス)

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Arterial thrombosis is the acute complication that develops on the chronic lesions of atherosclerosis and causes heart attack and stroke, today the most common causes of mortality in developed countries. Recent investigations indicate that atherosclerotic plaque disruption and subsequent thrombus formation might play a critical role in the clinical manifestations of atherothrombosis. Vulnerable lesions are characterized by the existence of core rich in lipid, inflammatory cells. The disruption of such vulnerable plaques facilitates the interaction between flowing blood and the inner components of disrupted lesions, triggering the coagulation cascade. Platelets, tissue factor, thrombin, fibrin and inflammatory cells are involved in this process of acute thrombus formation. In this review, we focus on the blood coagulation and fibrinolytic system in the mechanisms that lead to atherothrombosis.
日本アフェレシス学会の論文
2008-02-29

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