血管リモデリングとマトリックスメタロプロテイナーゼ(<特集>動脈硬化と細胞外マトリックス)

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Vascular remodeling, defined as any enduring change in the size and/or composition of blood vessels, allows adaptation and repair. Matrix metalloproteinases (MMPs) play an important role in vascular remodeling by degrading the extracellular matrix. Experimental evidence acquired in vitro and in vivo suggests that the major drives of vascular remodeling-hemodynamic stress, inflammation, and oxidative stress-regulate MMP expression and activity. Increased MMP expression has been detected in the atherosclerotic plaque, and activation of MMPs appears to be involved in the vulnerability of the plaque. Circulating MMP levels are elevated in patients with acute coronary syndrome. Increased MMP expression is also observed after coronary angioplasty, and is related to the late loss index after the procedure. These observations suggest that MMP expression may be related not only to instability of the plaque, but also to the formation of restenotic lesions. The development of therapeutic drugs targeted specifically against MMPs may be useful in the prevention of atherosclerotic lesion development, plaque rupture and restenosis.
日本結合組織学会の論文
2002-12-25

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