Positive and Negative Regulation of Radiation-induced Apoptosis by Protein Kinase C

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概要

• 論文の詳細を見る

• Indicators such as clonogenic survival, transformation, and chromosomal aberrations are used to evaluate the effects of radiation on cells. Apoptosis, another such indicator, is a mode of cell death, and radiation-induced apoptosis contributes to eliminating damaged cells and preventing malformation and carcinogenesis. Understanding radiation-induced apoptosis will assist in radiotherapy for cancer and treatment of patients in accidental radiation exposure. Protein kinase C (PKC) is a serine/threonine kinase that is related to cell proliferation, differentiation, metabolism, and apoptosis, and has many roles in the radiation-induced cellular responses involving apoptosis. This review describes the functions of PKC, including its relationship with other signaling networks and oxidative stress in the regulation of radiation-induced apoptosis. Such information might provide clues for evaluating the effects of radiation and for identifying clinical applications.

• 日本放射線影響学会の論文
• 2008-01-15

著者

• NAKAJIMA Tetsuo

  Radiation Effect Mechanisms Research Group, National Institute of Radiological Sciences

• Nakajima Tetsuo

  Radiation Effect Mechanisms Research Group Research Center For Radiation Protection National Institu

• Nakajima Tetsuo

  Radiat. Hazards Res. G. Nirs

関連論文

• Transcription Factor-recognition Sequences Potentially Involved in Modulation of Gene Expression after Exposure to Low-dose-rate γ-rays in the Mouse Liver
• Microarray Analysis of Differentially Expressed Genes in the Kidneys and Testes of Mice after Long-term Irradiation with Low-dose-rate γ-rays
• Induction of Rhodanese, a Detoxification Enzyme, in Livers from Mice after Long-term Irradiation with Low-dose-rate Gamma-rays
• 249 Prenatal Radiation-Induced Teratogenesis and Adaptive Response Modified by p53 and General Caspase Inhibitors(Apoptosis related, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Radiation-Induced Teratogenesis and Adaptive Response in the Late Period of Organogenesis in Mice : I. Dose Rate Effects
• Effects of Caspase Inhibitors on Nuclear Protein NP95 Depletion Associated with Radiation-induced Apoptosis in Murine ThymicLymphoma 3SB Cells.
• Involvement of Protein Kinase C in Radiation-induced Apoptosis Regulation in 3SBH5 Cells
• Low-Dose Irradiation Mediates Ca^ Signaling in Cultured Rat Hepatocytes
• 236 Distinct functions of protein kinase C subtypes in the regulation of radiation-induced apoptosis in murine thymic lymphoma cells(Apoptosis related, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Radioadaptation in Embryogenesis during Late Period of Organogenesis and Postnatal Retardation in the Prenatally Primed Mice
• Mechanism of Radiation-induced Diacylglycerol Production in Primary Cultured Rat Hepatocytes
• Characterizaton of CHO-cell mutants sensitive to active oxygen propagators (III).
• Low dose radiation-induced radical scavengers in rat liver and primary cultured rat hepatocytes.
• Positive and Negative Regulation of Radiation-induced Apoptosis by Protein Kinase C
• Gene Silencing of Tead3 Abrogates Radiation-induced Adaptive Response in Cultured Mouse Limb Bud Cells
• Transcription Factor-recognition Sequences Potentially Involved in Modulation of Gene Expression after Exposure to Low-dose-rate γ-rays in the Mouse Liver

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