DREF, a Transcriptional Regulatory Factor Related to Cell Proliferation

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概要

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• Coordinate expression of many cell proliferation-related genes is required for the cellular shift from resting state into proliferating state. For a candidate of the regulatory factors involved this process, we found a transcription regulatory factor named DREF (DNA replication-related element-binding factor) in Drosophila and then in mammalian systems. Drosophila DREF consists of a homodimer of the polypeptide of 709 amino acid residues, and shears about 22% identities of amino acid sequences with the human homolog which consists of 694 amino acid residues. Drosophila DREF binds specifically to the DRE sequence (5'-TATCGATA-3') in the promoters of many DNA replication/cell proliferation-related genes to activate their transcription. Ectopic expression of DREF in larval imaginal discs induce abnormal DNA synthesis, apoptosis and failures in differentiation. Both Drosophila and mammalian DREF's interact genetically and physically with regulatory factors related to chromatin structures, suggesting that DREF activates the expression of proliferation-related genes through modification of chromatin structures. By searching the Drosophila genome, we found about 150 genes which carry DRE sequences in their promoter regions, interestingly many of which are related to reactions required for cell proliferation such as DNA replication, transcription, transcriptional regulation, cell cycle regulation, growth signal transduction, protein metabolism. Thus, DREF is a master key-like factor for cell proliferation.

• お茶の水女子大学の論文

著者

• Inoue Makiko

  Department Of Chemical And Biological Sciences Japan Women's University

• Koike Akiko

  Department Of Health And Nutrition School Of Home Economics Wayo Women's University

• Koike Akiko

  Department Of Chemical And Biological Sciences Japan Women's University

• Koike Akiko

  Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University

• IKEDA Akiko

  Department of Quantum Matter, ADSM, Hiroshima University

• Matsukage A

  Department Of Chemical And Biological Sciences Faculty Of Science Japan Women's University

• Matsukage Akio

  Department Of Chemical And Biological Sciences Japan Women's University

• Maruyama Midori

  Department of Chemical and Biological Sciences, Japan Women's University

• Shuto Tomoko

  Department of Chemical and Biological Sciences, Japan Women's University

• Yoshida Hideki

  Kyoto Institute of Technology

• Yamaguchi Masamitsu

  Kyoto Institute of Technology

• Hirose Fumiko

  Aichi Cancer Center Research Institute

• Ikeda Akiko

  Department Of Chemical And Biological Sciences Japan Women's University

• Shuto Tomoko

  Department Of Chemical And Biological Sciences Japan Women's University

• Maruyama Midori

  Department Of Chemical And Biological Sciences Faculty Of Science Japan Women's University

• Yamaguchi Masamitsu

  Department Of Applied Biology Kyoto Institute Of Technology Graduate School

• Yoshida H

  Department Of Applied Biology Kyoto Institute Of Technology Graduate School

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