ナノサイズ白金微粒子含有水溶液の物理化学性状および生体作用

概要

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We have investigated physico-chemical properties and biological effects of colloidal platinum particles prepared by reduction of platinum salt and used for ingredients of food, beverages and skin cream. Firstly, aqueous dispersion of the 2〜3nm diameter particles was characterized by an ultraviolet-visible adsorption spectra and time domain reflectometry (TDR) method. The results showed the nano-size platinum particles exist as negatively charged colloids and do not interfere with dynamic behavior of water molecule in the aqueous phase. On the other hand, when the colloidal platinum particles were orally administrated to mice, all of the platinum was smoothly excreted within 48 hours. Toxicity and antibacterial tests showed the platinum particles were "negative", and no dermal absorption of the particles was found in in vitro measurements using a rat skin. These results led to conclusion that exposure to the colloidal platinum particles does not cause any adverse effects on living body.
東海大学の論文