EFFECT OF HEMOGLOBIN LEVEL ON CEREBRAL OPTICAL PROPERTIES IN NEWBORN PIGLETS DETERMINED BY NEAR-INFRARED TIME-RESOLVED-SPECTROSCOPY

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Near-infrared spectroscopy has been used for measurement of changes in cerebral hemoglobin concentration and oxygenation in humans. The purpose of this study was to investigate the effect of the arterial hemoglobin level on optical properties such as differential pathlength factor (DPF) and reduced scattering coefficient (μ's) in the brain. Five newborn piglets, less than 24h after birth, were used. To induce normovolemic anemia, 25ml of arterial blood was drew from the arterial catheter while infusing a same volume of 5% pig albumin solution via the peripheral vein. This procedure was performed 4 times for each piglet. We used a portable three-wavelength near-infrared time-resolved spectroscopy to measure the absorption coefficient, μ's and pathlength. The arterial hemoglobin concentration (Hba) was 13.3±2.4 g/dL at baseline and 3.5±0.6 g/dL at the completion of hemodilution. None of μ's at 761, 795 and 835 nm decreased significantly until the 4th hemodilution. Mean values of the difference subtracting 4th values from baseline values were 0.51, 0.49, and 0.52, respectively, only about 7% of the baseline value. DPFs at three wavelengths increased significantly along with progressive anemia due to hemodilution, which DPFs correlated logarithmically with Hba. DPFs at 761, 795 and 835 nm increased 19±9, 22±10 and 23±10% from baseline values after the 4 th hemodilution. The results demonstrated that arterial Hb concentration is the most important factor in determining the DPF and that red blood cells have little effect on total lightscattering in the brain.
名古屋市立大学の論文
2007-01-31

EFFECT OF HEMOGLOBIN LEVEL ON CEREBRAL OPTICAL PROPERTIES IN NEWBORN PIGLETS DETERMINED BY NEAR-INFRARED TIME-RESOLVED-SPECTROSCOPY

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