Body Distributioin of RGD-mediated Liposome in Brain-targeting Drug Delivery
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概要
- 論文の詳細を見る
RGD conjugation liposomes (RGD-liposomes) were evaluated for brain-targeting drug delivery. The flow cytometric in vitro study demonstrated that RGD-liposomes could bind to monocytes and neutrophils effectively. Ferulic acid (4-hydroxy-3-methoxycinnamic, FA) was loaded into liposomes. Rats were subjected to intrastriatal microinjections of 100 units of human recombinant IL-1β to produce brain inflammation and caudal vein injection of three formulations (FA solution, FA liposome and RGD-coated FA liposome). Animals were sacrificed 15, 30, 60 and 120 min after administration to study the body distribution of the FA in the three formulations. HPLC was used to determine the concentration of FA in vivo with salicylic acid as internal standard. The results of body distribution indicated that RGD-coated liposomes could be mediated into the brain with a 6-fold FA concentration compared to FA solution and 3-fold in comparison to uncoated liposome. Brain targeted delivery was achieved and a reduction in dosage might be allowed.
- 公益社団法人日本薬学会の論文
- 2007-09-01
著者
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CHEN Dawei
Department of Pharmaceutics, Shenyang Pharmaceutical University
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QIN Jing
Department of Mechanical Systems Engineering, Tokyo University of Agriculture and Technology
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Qiao Mingxi
Department Of Pharmaceutics School Of Pharmacy Shenyang Pharmaceutical University
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Qin Jing
Department Of Pharmaceutics School Of Pharmacy Shenyang Pharmaceutical University
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Chen Da
Department Of Information Management National Taiwan University Of Science And Technology:department
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Chen Dawei
School Of Pharmacy Shenyang Pharmaceutical Univ.
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HU HaiYang
Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University
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ZHAO XiuLi
Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University
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CHEN Bao
Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University
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Zhao Xiuli
School Of Pharmacy Shenyang Pharmaceutical Univ.
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Chen Bao
Department Of Pharmaceutics School Of Pharmacy Shenyang Pharmaceutical University
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Qin Jing
Department Of Mechanical Systems Engineering Tokyo University Of Agriculture And Technology
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Chen Dawei
Department Of Biopharmaceutics School Of Pharmacy Shenyang Pharmaceutical University
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Hu Hai
Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University
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