Preparation of N-Succinyl-chitosan and Their Physical-Chemical Properties as a Novel Excipient

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概要

• 論文の詳細を見る

• The aim of this work is to prepare N-succinyl-chitosan (Suc-Chi) and measure physical-chemical properties for Suc-Chi as excipients. Suc-Chi were prepared via ring-opening reactions with succinic anhydride in Dimethyl Sulfoxide system. The physical-chemical properties of Suc-Chi, such as the degree of substitution (DS) , solubility, isoelectric point (pI) , glass transition temperature (Tg), partition coefficient (P_<app>) and zata potential were detected respectively in order to evaluate their possibility as drug carriers. We obtained Suc-Chi DAC-90 (DS=0.33) and the data of physical-chemical properties for the product. The knowledges of physical-chemical properties for Suc-Chi are valuable for basic or applied purposes in biomedical and pharmaceutical sciences stabilization.

• 公益社団法人日本薬学会の論文
• 2006-09-01

著者

• Gu Jiwei

  College of Chemistry & Pharmacy, University of Jiamusi

• Qiao Mingxi

  Department Of Pharmaceutics School Of Pharmacy Shenyang Pharmaceutical University

• Chen Dawei

  School Of Pharmacy Shenyang Pharmaceutical Univ.

• HU HaiYang

  Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University

• ZHAO XiuLi

  Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University

• YAN Chengyun

  Box 42, School of Pharmacy, Shenyang Pharmaceutical University

• CHEN Dawei

  Box 42, School of Pharmacy, Shenyang Pharmaceutical University

• HU Haiyang

  Box 42, School of Pharmacy, Shenyang Pharmaceutical University

• ZHAO Xiuli

  Box 42, School of Pharmacy, Shenyang Pharmaceutical University

• QIAO Mingxi

  Box 42, School of Pharmacy, Shenyang Pharmaceutical University

• Zhao Xiuli

  School Of Pharmacy Shenyang Pharmaceutical Univ.

• Gu Jiwei

  College of Chemistry & Pharmacy, Jiamusi of University

関連論文

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