Construction of the Fingerprints of Ginseng Stem and Leaf Saponin Reference Substances and Spiked Plasma Sample by LC-ESI/MS and Its Application to Analyzing the Compounds Absorbed into Blood after Oral Administration of Ginseng Stem and Leaf Saponin in R
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概要
- 論文の詳細を見る
Develop a simple and reliable assay method to detect ginseng stem and leaf saponins (GSLS) in methanol and rat plasma by liquid chromatography-electrospray ionization mass spectrometry in scan mode, and construct the fingerprints of GSLS reference substances and plasma samples. In order to screen the active constituents of GSLS, analysis and comparison were carried out between the LC/ESI-MS profiles of blank rat plasma and rat plasma samples obtained after oral administration of GSLS. Thirty-one compounds were detected and 10 of them were identified in the fingerprints of reference substances and spiked plasma sample. Furthermore, 12 compounds (C7, C8, C14, C15, C18, Re, C24, Rb_1, Rc, Rb_2, Rb_3, Rd) were absorbed easily and some new compounds were generated after oral administration of GSLS, which might be the metabolites of GSLS. These absorbed components and new compounds may be the main bioactive components of GSLS.
- 公益社団法人日本薬学会の論文
- 2007-09-01
著者
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WANG Guangji
Key Laboratory of Pharmacokinetics and Drug Metabolism, China Pharmaceutical University
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LIANG Yan
Key Laboratory of Organic-Optoelectronics and Molecular Engineering of the Ministry of Education, De
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Wang Guang-ji
Key Laboratory Of Pharmacokinetics And Drug Metabolism China Pharmaceutical University
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Wang Guangji
Key Lab Of Drug Metabolism And Pharmacokinetics China Pharmaceutical University
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Wang Guangji
Key Laboratory Of Drug Metabolism & Pharmacokinetics China Pharmaceutical University
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LI Xiaoyu
Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University
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XIE Lin
Key Lab of Drug Metabolism & Pharmacokinetics E04#, China Pharmaceutical University
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ZHENG Yuanting
Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University
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SUN Jianguo
Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University
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HAO Haiping
Key laboratory of Drug Metabolism and Pharmacokinetics
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A Jiye
Key Laboratory of Drug Metabolism & Pharmacokinetics, China Pharmaceutical University
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A Jiye
Key Laboratory Of Drug Metabolism & Pharmacokinetics China Pharmaceutical University
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Xie Lin
Key Lab Of Drug Metabolism & Pharmacokinetics China Pharmaceutical University
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Li Xiaotian
Key Laboratory Of Drug Metabolism And Pharmacokinetic China Pharmaceutical University
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Li Xiaoyu
Key Lab Of Drug Metabolism And Pharmacokinetics China Pharmaceutical University
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Liang Yan
Key Laboratory Of Drug Metabolism And Pharmacokinetics China Pharmaceutical University
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Liang Yan
Key Lab Of Drug Metabolism & Pharmacokinetics China Pharmaceutical University
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Wang Guang-ji
Key Lab Of Drug Metabolism & Pharmacokinetics China Pharmaceutical University
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Hao Haiping
Key Lab Of Drug Metabolism And Pharmacokinetics China Pharmaceutical University
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Sun Jianguo
Key Lab Of Drug Metabolism And Pharmacokinetics China Pharmaceutical University
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Sun Jianguo
Key Laboratory Of Drug Metabolism & Pharmacokinetics China Pharmaceutical University
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Zheng Yuanting
Key Laboratory Of Drug Metabolism And Pharmacokinetic China Pharmaceutical University
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YAN Bei
Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University
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Yan Bei
Key Laboratory Of Drug Metabolism And Pharmacokinetic China Pharmaceutical University
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Li Xiaotian
Key Laboratory Of Drug Metabolism And Pharmacokinetics China Pharmaceutical University
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Hao Haiping
Key Lab Of Drug Metabolism & Pharmacokinetics China Pharmaceutical University
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Xie Lin
Key Laboratory Of Drug Metabolism And Pharmacokinetics China Pharmaceutical University
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