Pharmacokinetic and Absolute Bioavailability Study of Total Panax Notoginsenoside, a Typical Multiple Constituent Traditional Chinese Medicine (TCM) in Rats(Analytical Biochemistry)
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概要
- 論文の詳細を見る
LC/ESI/MS method was employed for the pharmacokinetic evaluation of total panax notoginsenoside (TPNS) in rats. After oral or intravenous administration of TPNS at the dosage of 300.0 or 10.0 mg kg^<-1> to rats respectively, panax notoginsenoside R1, ginsenoside Rg1, Rd, Re and Rb1 were simultaneous determined in rat plasma. Pharmacokinetic parameters and absolute bioavailability of panax notoginsenoside R1, ginsenoside Rg1, Rd, Re and Rb1 were obtained by the Drug And Statistics for windows (DAS) pharmacokinetic software. The pharmacokinetic parameters of all analytes were different form each other. T_<1/2> were changed from 0.72 to 22.16 h and AUC were changed from 1.03 to 98.94 mg/1・h after oral or intravenous administration TPNS or Xuesaitong (TPNS) injection. The absolute bioavailability of R1, Rg1, Rd, Re and Rb1 were of 9.29%, 6.06%, 2.36%, 7.06% and 1.18%, respectively.
- 公益社団法人日本薬学会の論文
- 2007-05-01
著者
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WANG Guangji
Key Laboratory of Pharmacokinetics and Drug Metabolism, China Pharmaceutical University
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Wang Guang-ji
Key Laboratory Of Pharmacokinetics And Drug Metabolism China Pharmaceutical University
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Wang Guangji
Key Lab Of Drug Metabolism And Pharmacokinetics China Pharmaceutical University
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Wang Guangji
Key Laboratory Of Drug Metabolism & Pharmacokinetics China Pharmaceutical University
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LI Xiaoyu
Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University
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ZHENG Yuanting
Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University
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SUN Jianguo
Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University
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HAO Haiping
Key laboratory of Drug Metabolism and Pharmacokinetics
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Liu Xiaodong
Key Laboratory Of Drug Metabolism And Pharmacokinetics China Pharmaceutical University
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Li Xiaotian
Key Laboratory Of Drug Metabolism And Pharmacokinetic China Pharmaceutical University
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Li Xiaoyu
Key Lab Of Drug Metabolism And Pharmacokinetics China Pharmaceutical University
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Wang Guang-ji
Key Lab Of Drug Metabolism & Pharmacokinetics China Pharmaceutical University
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Hao Haiping
Key Lab Of Drug Metabolism And Pharmacokinetics China Pharmaceutical University
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Sun Jianguo
Key Lab Of Drug Metabolism And Pharmacokinetics China Pharmaceutical University
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Sun Jianguo
Key Laboratory Of Drug Metabolism & Pharmacokinetics China Pharmaceutical University
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Zheng Yuanting
Key Laboratory Of Drug Metabolism And Pharmacokinetic China Pharmaceutical University
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XIONG Yuqing
Clinical Pharmacology Institute, Medical College of Nanchang University
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YAN Bei
Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University
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XIONG Yuqing
Institute of Clinical Pharmacology, Medical College of Nanchang University
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SHENG Longsheng
Center for Instrumental Analysis, China Pharmaceutical University
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Yan Bei
Key Laboratory Of Drug Metabolism And Pharmacokinetic China Pharmaceutical University
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Xiong Yuqing
Clinical Pharmacology Institute Medical College Of Nanchang University
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Sheng Longsheng
Center For Instrumental Analysis China Pharmaceutical University
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Li Xiaotian
Key Laboratory Of Drug Metabolism And Pharmacokinetics China Pharmaceutical University
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Hao Haiping
Key Lab Of Drug Metabolism & Pharmacokinetics China Pharmaceutical University
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Xie Lin
Key Laboratory Of Drug Metabolism And Pharmacokinetics China Pharmaceutical University
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Li Xiaotian
Key Lab Of Drug Metabolism & Pharmacokinetics China Pharmaceutical University
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