Pharmacokintics of the Ginkgo Bfollowing Intravenous Administration of Ginkgo B Emulsion in Rats(Analytical Biochemistry)
スポンサーリンク
概要
- 論文の詳細を見る
Ginkgo B (GB) is an extract from the leaves of Ginkgo biloba, used in the treatment of dementia, cerebral insufficiency or related cognitive decline. In this paper, the main features of the pharmacokinetics of GB emulsion in rats were reviewed and the binding rate of GB to rat plasma and human plasma protein were investigated meanwhile. The concentrations of GB in plasma, tissue, and excretion of rats after i.v. administration of GB were measured using HPLC-ESI-MS. The metabolite was qualitated by LC-MS/MS. Intravenously administered GB was eliminated in a biphasic manner with a prominent initial phase (half-life of 0.3h) followed by a slower terminal phase (half-life of 1.5h). After i.v. 4, 12 and 36mg/kg GB emulsion, the pharmacokinetic parameters from a two compartment model analysis of plasma samples were AUC_<0-τ> (μg・min/ml): 53.7, 165.5 and 649.7; CL (l/min/kg): 0.07, 0.07 and 0.05; V_c (l/kg): 2.27, 3.27 and 2.76, respectively. Peak concentrations generally occurred at 10 min except brain and fat. Tissue concentration then declined by several-fold during 6h although still present in most tissues at 6h. Single intravenous dose was mainly excreted in the urine (40-50%), fece contained less than 30%. The binding rate to rat plasma was little higher than to human plasma, but the difference was negligible. Some metabolites were found in urine and bile through qualitative analysis on the urine and bile by LC-MS/MS.
- 公益社団法人日本薬学会の論文
- 2007-01-01
著者
-
WANG Guangji
Key Laboratory of Pharmacokinetics and Drug Metabolism, China Pharmaceutical University
-
Chen Wei-dong
Key Lab Of Drug Metabolism & Pharmacokinetics China Pharmaceutical University:the Hospital Of Th
-
LIANG Yan
Key Laboratory of Organic-Optoelectronics and Molecular Engineering of the Ministry of Education, De
-
Wang Guang-ji
Key Laboratory Of Pharmacokinetics And Drug Metabolism China Pharmaceutical University
-
Wang Guangji
Key Lab Of Drug Metabolism And Pharmacokinetics China Pharmaceutical University
-
Wang Guangji
Key Laboratory Of Drug Metabolism & Pharmacokinetics China Pharmaceutical University
-
XIE Lin
Key Lab of Drug Metabolism & Pharmacokinetics E04#, China Pharmaceutical University
-
LU Tong
Key Lab of Drug Metabolism & Pharmacokinetics, China Pharmaceutical University
-
LIU Xiao-Dong
Key Lab of Drug Metabolism & Pharmacokinetics, China Pharmaceutical University
-
Lu Tong
Key Lab Of Drug Metabolism & Pharmacokinetics China Pharmaceutical University
-
Liu Xiaodong
Key Laboratory Of Drug Metabolism And Pharmacokinetics China Pharmaceutical University
-
Xie Lin
Key Lab Of Drug Metabolism & Pharmacokinetics China Pharmaceutical University
-
Liu Xiao-dong
Key Lab Of Drug Metabolism & Pharmacokinetics China Pharmaceutical University
-
Liang Yan
Key Laboratory Of Drug Metabolism And Pharmacokinetics China Pharmaceutical University
-
Liang Yan
Key Lab Of Drug Metabolism & Pharmacokinetics China Pharmaceutical University
-
Wang Guang-ji
Key Lab Of Drug Metabolism & Pharmacokinetics China Pharmaceutical University
-
Xie Lin
Key Laboratory Of Drug Metabolism And Pharmacokinetics China Pharmaceutical University
関連論文
- Quantitative determination of helicid in rat plasma by liquid chromatography-electrospray ionization mass spectrometry and its application to preliminary pharmacokinetic studies
- Research on Operating Degradation of Pentacene Thin-Film Transistors
- Determination of ginsenoside Rd in dog plasma by liquid chromatography-mass spectrometry after solid-phase extraction and its application in dog pharmacokinetics studies
- Determination of schizandrin in rat plasma by high-performance liquid chromatography-mass spectrometry and its application in rat pharmacokinetic studies
- High performance liquid chromatographic-mass spectrometric determination of ginsenoside Rg3 and its metabolites in rat plasma using solid-phase extraction for pharmacokinetic studies
- Uptake and Metabolism of Ginsenoside Rh2 and Its Aglycon Protopanaxadiol by Caco-2 Cells(Biopharmacy)
- Simple, sensitive and rapid LC-MS method for the quantitation of indapamide in human plasma-application to pharmacokinetic studies
- Quantitative determination of trans-polydatin, a natural strong anti-oxidative compound, in rat plasma and cellular environment of a human colon adenocarcinoma cell line for pharmacokinetic studies
- Pharmacokintics of the Ginkgo Bfollowing Intravenous Administration of Ginkgo B Emulsion in Rats(Analytical Biochemistry)
- Development and validation of a liquid chromatographic/electrospray ionization mass spectrometric method for the determination of salidroside in rat plasma : Application to the pharmacokinetics study
- In Vitro Assessment of Plasma Protein Binding of 20(R)-Ginsenoside Rh2 by Equilibrium Dialysis and LC-MS Analysis : A Case of Species Differences(Pharmacology)
- Quantitative determination of atractylenolide III in rat plasma by liquid chromatography electrospray ionization mass spectrometry
- Pharmacokinetic Study of Triptolide, a Constituent of Immunosuppressive Chinese Herb Medicine, in Rats(Pharmacology)
- Unidirectional Inversion of Ibuprofen in Caco-2 Cells : Developing a Suitable Model for Presystemic Chiral Inversion Study(Biopharmacy)
- Simultaneous determination of ginsenoside Rg1, Re, Rd, Rb1 and ophiopogonin D in rat plasma by liquid chromatography/electrospray ionization mass spectrometric method and its application to pharmacokinetic study of 'SHENMAI' injection
- Construction of the Fingerprints of Ginseng Stem and Leaf Saponin Reference Substances and Spiked Plasma Sample by LC-ESI/MS and Its Application to Analyzing the Compounds Absorbed into Blood after Oral Administration of Ginseng Stem and Leaf Saponin in R
- Pharmacokinetic and Absolute Bioavailability Study of Total Panax Notoginsenoside, a Typical Multiple Constituent Traditional Chinese Medicine (TCM) in Rats(Analytical Biochemistry)
- Pharmacokinetics of Guanfu Base I, an Active Metabolite of Guanfu Base A, in Rats(Analytical Biochemistry)
- Simultaneous determination of oxymatrine and its active metabolite matrine in dog plasma by liquid chromatography-mass spectrometry and its application to pharmacokinetic studies
- A simple and sensitive HPLC-ESI-MS/MS method for the determination of andrographolide in human plasma
- Determination of betamethasone and betamethasone 17-monopropionate in human plasma by liquid chromatography-positive/negative electrospray ionization tandem mass spectrometry
- Quantitative determination of helicid in rat biosamples by liquid chromatography electrospray ionization mass spectrometry
- Development and validation of a liquid chromatography-mass spectrometry method for the determination of verticinone in rat plasma and its application to pharmacokinetic study
- Validation and application of an LC-ESI-MS method for simultaneous determination of astilbin and its major metabolite 3'-O-methylastilbin in rat plasma
- Organic solvent extraction and metabonomic profiling of the metabolites in erythrocytes
- CJK-P-01 Appling Metabolomics to the Investigation on Anti-Sport Fatigue Effects of Korean Ginseng Given to Professional Athletes
- Research on Operating Degradation of Pentacene Thin-Film Transistors