Isolation and Structural Identification of a New Cross-linking Amino Acid, Allodesmosine, from the Acid Hydrolysate of Elastin(Biological Chemistry)

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概要

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• A new polyfunctional cross-linking amino acid was isolated from the hydrolysate of bovine ligamentum nuchae elastin. This compound was a very hygroscopic, white amorphous solid with a faint yellow tinge, and was soluble in aqueous solvents but not in dry methanol. Its proposed structure was verified by ultraviolet spectroscopy, fast atom bombardment mass spectroscopy, and ^1H- and ^<13>C-nuclear magnetic resonace spectroscopy. The data indicated it to be a pentafunctional amino acid with a quaternary pyridinium structure similar to desmosine. The mass spectral analysis indicated a parent compound with a mass of 655 (C_<30>H_<51>N_6O_<10>). The proposed structure is one derived from the condensation of one lysine residue and four allysine residues. Based on the names of other cross-linking amino acids found in elastin, the trivial name of allodesmosine is given for this compound. Allodesmosine was also detected in hydrolysates of bovine lung, aorta and skin by high-performance liquid chromatography.

• 社団法人日本農芸化学会の論文
• 1991-02-23

著者

• Suyama Kyozo

  Laboratory Of Animal Products Technology Faculty Of Agriculture Tohoku University

• Nakamura Fumihiko

  Laboratory Of Molecular Technology Of Animal Products Faculty Of Agriculture Tohoku University

関連論文

• Isoraffinose(6^G-β-galactosylsucrose) Synthesized by the Intermolecular Transgalactosylation Reaction of Escherichia coli β-Galactosidase(Food & Nutrition)
• Aldosine, an Acid Hydrolysis Product from the Aldol Cross-link of Bovine Elastin and Collagen(Organic Chemistry)
• Isolation and Structural Identification of a New Cross-linking Amino Acid, Allodesmosine, from the Acid Hydrolysate of Elastin(Biological Chemistry)

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