Inclusion Complexes of Poorly Water-Soluble Drugs with Glucosyl-cyclodextrins(Pharmaceutical)

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概要

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• The inclusion complex-forming ability of three glucosyl-cyclodextrins (CDs), 6-О-α-D-glucosyl-α-CD (G-α-CD), 6-О-α-D-glucosyl-β-CD (G-β-CD), and 6^A,6^D-di-О-α-D-glucosyl-β-CD (2G-β-CD) with slightly soluble or insoluble drugs in aqueous solution and in the solid state was studied by the solubility method, ultraviolet spectroscopy, and differential scanning calorimetry. These glucosyl-CDs were capable of forming inclusion complexes with compounds which can form complexes with the parent CDs. The enhancement of solubility of poorly water-soluble drugs by glucosyl-β-CDs was much more marked than that by β-CD. The hemolytic activity of glucosyl-CD was lower than that of each parent CD. The estriol-glucosyl-β-CD complex may be practically applicable to injectable preparations because of its high water-solubility and low hemolytic activity.

• 公益社団法人日本薬学会の論文
• 1987-08-25

著者

• Koizumi Kyoko

  Faculty Of Pharmaceutical Sciences Mukogawa Women's University

• Kubota Y

  Kumamoto Univ. Kumamoto Jpn

• Okada Y

  Kobe‐gakuin Univ. Kobe Jpn

• OKADA YASUYO

  Faculty of Pharmaceutical sciences, Mukogawa Women's University

• KUBOTA YOKO

  Faculty of Pharmaceutical sciences, Mukogawa Women's University

• KUBOTA YOKO

  Faculty of Pharmaceutical sciences, Mukogawa Women's University

• OKADA YASUYO

  Faculty of Pharmaceutical sciences, Mukogawa Women's University

関連論文

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• Synthesis of 6-O-α-D-Galactosyl α-Cyclodextrin by Coffee Bean α-Galactosidase
• Acceptor Specificity of Cyclodextrin Glycosyltransferase from Bacillus stearothermophilus and Synthesis of α-D-Glucosyl O-β-D-galactosyl-(1→4)-β-D-glucoside
• Galactosylation at Side Chains of Branched Cyclodextrins by Various β-Galactosidases
• Galactosylation of Cyclodextrins and Branched Cyclodextrins by α-Galactosidases
• Acceptor Specificities of α-Mannosidases from Jack Bean and Almond, and Trans-mannosylation of Branched Cyclodextrins
• Chemical Structures of Hetero-oligosaccharides Produced by Arthrobacter sp. K-1β- Fructofuranosidase
• Inclusion Complexes of Poorly Water-Soluble Drugs with Glucosyl-cyclodextrins(Pharmaceutical)

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