Singlet Oxygen-Producing Activity and Photodynamic Biological Effects of Acridine Compounds(Biological)
スポンサーリンク
概要
- 論文の詳細を見る
The singlet oxygen-producing activities and photodynamic biological activities of acridine compounds were compared. Singlet oxygen was trapped by 2,2,6,6-tetramethyl-4-piperidone(TEMP), and 2,2,6,6-tetramethyl-4-piperidone-N-oxyl(TEMPO) produced was detected by electron spin resonance(ESR) spectrometry. TEMPO production was inhibited by NaN_3 and enhanced in D_2O, confirming it to be an adequate ESR spectroscppic indicator for singlet oxygen. Comparison of TEMPO-producing activities revealed that acriflavine and proflavine, which are the most potent photosensitizers both in cell inactivation and petite induction of yeast, produced the most intense and long-lived ESR signals. However there was no clear difference of TEMPO-producing activity between biologically ineffective acridines such as acridine and quinacrine and effective ones such as acridine yellow and 6,9-diamino-2-ethoxyacridine. These results suggested that the differences observed in the photodynamic biological effects among the acridine compounds depend mainly on the differences of drug distribution and only partly on the differences of singlet oxygen-producing activity of the dye molecule itself.
- 社団法人日本薬学会の論文
- 1987-06-25
著者
-
岩本 義久
Department Of Microbiology School Of Pharmaceutical Sciences University Of Shizuoka
-
柳原 保武
Department Of Microbiology School Of Pharmaceutical Sciences University Of Shizuoka
-
岩本 義久
Shizuoka College of Pharmacy
-
吉岡 寿
Shizuoka College of Pharmacy
-
柳原 保武
Shizuoka College of Pharmacy
-
吉岡 寿
Graduate School Of Nutritional And Environmental Sciences University Of Shizuoka
関連論文
- Comparison of Flanking Regions of the 5S Ribosomal Ribonucleic Acid Genes in Leptospira biflexa and Leptospira interrogans
- ESR Investigation of the Rotational Mobility of Spin Probes in Ethanol Solvent Adsorbed to β-Cyclodextrin
- A Novel Spin Probe with Long Life in Vivo for ESR Imaging
- Antitumor Activity and Lethal Toxicity of Chemically Synthesized Tetraacetyl-2-keto-3-deoxyoctonic Acid-(α2→6)-D-glucosamine Analogues of Lipid A(Biological)
- Comparison of Biological Activities of Chemically Synthesized Monosaccharide Analogues of Reducing and Nonreducing Sugar Moieties of Lipid A(Blological)
- MITOGENIC ACTIVITY OF CHEMICALLY SYNTHESIZED TETRAACETYL-2-KETO-3-DEOXYOCTONIC ACID-(α 2→6)-D-GLUCOSAMINE ANALOGUES OF LIPID A
- ANTITUMOR ACTIVITY AND BIOLOGICAL EFFECTS OF CHEMICALLY SYNTHESIZED MONOSACCHARIDE ANALOGUES OF LIPID A IN MICE
- Mitogenic Activity and the Induction of Tumor Necrosis Factor by Lipopeptide Analogs of the N-Terminal Part of Lipoprotein in the Outer Membrane of Escherichia coli
- DNA Strand-Breaking Activities of Quinolone Antimicrobial Agents under Visible Light Irradiation
- Photodynamic DNA Strand Breaking Activities of Acridine Compounds
- Mitogenic Activity and Lethal Toxicity of Lipid A Analogs, Glucosamine-phosphate Carrying Aromatic Alkyl Groups, in Mice
- Low Mitogenic Activity of Synthetic Lipid A Analog, 2,3-Acyloxyacylgalactosamine-4-phosphate, in Cultured Murine Splenocytes
- Photodynamic Deoxyribonucleic Acid (DNA) Strand Breaking Activities of Enoxacin and Afloqualone
- Photodynamic Activities of Food Additive Dyes on the Yeast Saccharomyces cerevisiae
- Monoclonal Antibody against Leptospira interrogans serovar canicola
- Mutagenicity Tests with a Permeable Mutant of Yeast on Carcinogens Showing False-Negative in Salmonella Assay
- Leptospira interrogans serovar canicola Moulton株から抽出したリポ多糖体様物質(LLS)の化学的性状(発表論文抄録(1987年))
- Singlet Oxygen-Producing Activity and Photodynamic Biological Effects of Acridine Compounds(Biological)
- Petite Induction in Yeast, Saccharomyces cerevisiae, by Phenanthridinium Compounds : Promotive Effects of Propidium Iodide on Mutagenesis by Ethidium Bromide or 8-Deaminoethidium Chloride
- Electron Spin Resonance Detection of Singlet Oxygen Produced in Irradiated Acriflavine Solutions
- Induction of "Petite" Mutants of Yeast, Saccharomyces cerevisiae, by Photodynamic Action of Acriflavine
- Superoxide Dismutase Activity of Lactobacilli
- Isolation of Antimycin-resistant Variants of Candida utilis
- Isolation of Cytochrome c Abundant Mutant of Candida utilis
- Comparison of Cross-Reactivities of Imipenem and Other Beta-Lactam Antibiotics by Delayed-Type Hypersensitivity Reaction in Guinea Pigs
- Immunological Properties of Cephalexin-Induced Delayed Type Hypersensitivity Reaction in Guinea Pigs
- Macrophage Activation and Immunostimulating Activity of Sphaerotilus natans and Its Slime Fraction(Biological)
- Mitogenicity and Adjuvanticity of Lipopolysaccharide from a Marine Bacterium, Vibrio anguillarum, in Mice
- Osmotic-Sensitive Mutants of Saccharomyces cerevisiae as Screening Organisms for Promutagens and Procarcinogens
- Electron Spin Resonance Study of γ-Irradiated H_2SO_4-SiO_2 System