Antitumor Mechanisms of Orally Administered Shiitake Fruit Bodies(Biological)

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When tumor-bearing mice were given diet containing fruit bodies of shiitake (L-feed), the tumor growth was apparently inhibited. To elucidate the mechanisms of this action, the effects of the L-feed on the production superoxide anion (SOA) by macrophages and the cytotoxicity of natural killer T cells were studied. When MM-46 carcinoma-bearing C3H mice were maintained on L-feed(containing 20% shiitake powder), SOA production by macrophages was increased about 2.0 to 2.3times. Furthermore, the cytotoxic activities of natural killer cells and killer T cells were increased 1.9times and 1.4times, compared with their counterparts from normal C3H mice fed on shiitake-freediet. These results suggest that shiitake powder given orally activates various effector cells to attacktumor cells. It appears to potentiate cellular functions and at the same time to prevent a decrease of immune function of the tumor-bearing host.
1987-06-25