Antitumor Activity Exhibited by Orally Administered Extract from Fruit Body of Grifola frondosa (Maitake)

スポンサーリンク

概要

• 論文の詳細を見る

• The acid-insoluble, alkali-soluble, hot-water-extractable polymer (a polysaccharide containing approximately 30% of protein; D-fraction) obtained from the fruit bodies of Grifola frondosa (maitake) exhibited antitumor activities against allogenic and syngeneic tumors on oral administration to mice. Winn assay conducted to examine the tumor growth-suppressing effect revealed a complete inhibition of the tumor by the oral administration of D-fraction. This fact indicates that stimulation of the immune response system triggered by the tumor-bearing state is activated by D-fraction. Consequently, the activity of D-fraction on cells associated with immune response was examined. The cytolytic activity and interleukin-1 productivity of macrophages or T cells which exhibit antigen-specific cytotoxicity were enhanced. D-fraction was found to potentiate the delayed-type hypersensitivity response which is associated with tumor growth suppression.

• 公益社団法人日本薬学会の論文
• 1988-05-25

著者

• 灘波 宏彰

  Laboratory Of Microbiology Kobe Women's College Of Pharmacy

• 黒田 久寅

  Laboratory Of Microbiology Kobe Women's College Of Pharmacy

• 菱田 郁子

  Laboratory of Microbiology, Kobe Women's College of Pharmacy

• 菱田 郁子

  Laboratory Of Microbiology Kobe Women's College Of Pharmacy

関連論文

• Potentiation of Host-Mediated Antitumor Activity by Orally Administered Mushroom (Agaricus bispora) Fruit Bodies
• Antitumor Mechanisms of Orally Administered Shiitake Fruit Bodies(Biological)
• Antitumor Action of Shiitake(Lentinus edodes) Fruit Bodies Orally Administered to Mice(Biological)
• Potentiating Effect of β-Glucan from Cochliobolus miyabeanus on Host-Mediated Antitumor Activity in Mice(Biological)
• The Chemical Structure of an Antitumor Polysaccharide in Mycelia of Cochliobolus miyabeanus(Biological)
• The Chemical Structure of an Antitumor Polysaccharide in Fruit Bodies of Grifola frondosa (Maitake)(Biological)
• Antitumor Activity Exhibited by Orally Administered Extract from Fruit Body of Grifola frondosa (Maitake)
• Lipopolysaccharide-like Substance isolated from Mycelia of Cochliobolus miyabeanus
• Studies on Fungicides. XIII. Lipids Compositions of Conidia of Cochliobolus miyabeanus and Their Changes during Spore Germination

スポンサーリンク