Potentiating Effect of β-Glucan from Cochliobolus miyabeanus on Host-Mediated Antitumor Activity in Mice(Biological)
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概要
- 論文の詳細を見る
The polysaccharide As-I, a β-1,3 glucan possessing 1,6-linked side chains, isolated from mycelia of Cochliobolus miyabeanus (Ascomycetes), inhibited the growth of Sarcoma 180 solid tumor in ICR mice. As-I also inhibited the growth of solid tumors of IMC-carcinoma in CDF_1 mice by 32% and that of solid tumors of MM-46 carcinoma in C3H mice by 99.3% at 0.1 mg/kg/d (10 times). However, As-I has no direct cytotoxic activity against tumor cells. The effect of As-I on macrophages was studied, because branched β-1,3 glucans may stimulate cellular immunity. As-I activated macrophage spreading and phagocytosis of tumor cells. Accordingly, the antitumor activity of As-I might be host-mediated, like that of other β-1,3 glucans.
- 1987-03-25
著者
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黒田 久寅
Kobe Women's College Of Pharmacy
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難波 宏彰
Laboratory Of Microbiology Kobe Women's College Of Pharmacy
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黒田 久寅
Laboratory Of Microbiology Kobe Women's College Of Pharmacy
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