COPDにおける低用量テオフィリンの気道抵抗, 呼吸筋力および高感度CRPへの影響

概要

論文の詳細を見る
The purpose of this study was to evaluate the effect of low-dose theophylline on airway resistance (Raw), respiratory muscle strength and high-sensitivity CRP in patients with chronic obstructive pulmonary disease (COPD). The subjects were 11 patients with COPD (8 males; 3 females). Raw and other pulmonary function parameters were measured by means of body plethysmography. Maximal expiratory pressure (MEP) and the maximal inspiratory pressure (MIP), the parameters of respiratory muscle strength, were measured after 4 weeks of administering low-dose theophylline when serum concentrations of theophylline were 4.7±2.9 micro g/mL. The administration of theophylline decreased Raw, significantly increased FEV 1.0, decreased CRP levels and increased MEP. High-sensitivity CRP levels were negatively correlated with MEP and MIP (R^2=0.474, R^2=0.657 respectively). The results of the present study suggested that high-sensitivity CRP can be used as an indicator of respiratory muscle strength in patients with COPD.
日本医療薬学会の論文
2007-02-10