Prune Extract (Prunus Domestica L.) Suppresses the Proliferation and Induces the Apoptosis of Human Colon Carcinoma Caco-2

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概要

• 論文の詳細を見る

• Prunes are the dried fruits of certain cultivars of Prunus domestica L., and are recognized as a health food. The separated ethanol fraction from concentrated prune juice by DIAION HP-20 (PE) was investigated for cytotoxic effects on two different cancer cell lines in vitro. PE dose-dependently reduced the viable cell number of Caco-2, KATO III, but does not reduce the viable cell number of human normal colon fibroblast cells (CCD-18Co) used as a normal cell model. PE treatment for 24 h led to apoptotic changes in Caco-2 such as cell shrinkage and blebbed surfaces due to the convolutions of nuclear and plasma membranes and chromatin condensation, but this was not observed in CCD-18Co. PE induced nucleosomal DNA fragmentation typical of apoptosis in Caco-2 after 24 h of treatment. These results show that PE induced apoptosis in Caco-2. Furthermore, by Caco-2 treatment with H_2O_2 chelator catalase and Ca^<2+> -chelator BAPTA/AM, the PE-induced cytotoxic pathway was completely blocked, and the viable cell number of Caco-2 was not affected.

• 日本ビタミン学会の論文

著者

• IKEDA Katsumi

  Frontier Health Science Forum, Mukogawa Women's University

• Ikeda K

  Department Of Pharmacy Mukogawa Women's University

• Ikeda Katsumi

  就実大学 薬学部応用薬学

• XU Jin-Wen

  Frontier Health Science, School of Human Environmental Sciences, Mukogawa Women's University

• IKAMI Takao

  Research and Development Institute, MIKI Corporation

• FUJII Takashi

  Research and Development Institute, MIKI Corporation

• Xu Jin-wen

  武庫川女子大学 薬学部

• Xu Jin-wen

  School Of Human Environmental Science Mukogawa Women's University

• Ikami Takao

  Research And Development Institute Miki Corporation

• Ikami Takao

  Research & Development Institute Miki Corporation

• Ikeda Katsumi

  Frontier Health Science Forum Mukogawa Women's University

• Xu Jin-wen

  Frontier Health Science School Of Human Environment Science Mukogawa Women's University

• Ikeda Katsumi

  Frontier Health Science School Of Human Environment Science Mukogawa Women's University

• Fujii Takashi

  Research And Development Institute Miki Corporation

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