実験的ラット口腔癌発生におよぼす遺伝的要因 : 付・4NQO誘発ラット口腔癌について

概要

論文の詳細を見る
The genetic background in relation to the susceptibility to experimental oral carcinogenesis in rats was reviewed. As an experimental model, 4-nitroquinoline 1-oxide (4 NQO)-induced rat carcinoma is thought to be excellent. Because it demonstrates obvious organtropic, species and straas specificity in its carcinogenesis. Administration of 4 NQO-solution as drinking water produces oral carcinomas in rats with a high incidence. We described strain differences on susceptibility to 4 NQO-induced rat carcinoma especially of the tongue concerning 1) enzymal activity of 4 NQO metabolism, 2) 4-hydroxyaminoquinoline 1-oxide (4 HAQO)-DNA adduct formation (4 HAQO is the proximate carcinogenic derivative from 4 NQO), 3) DNA repair processes, and 4) immunological response comparing various strains of rats, to clarify the genetic controls on the experimental carcinogenesis in rats.
1991-03-26