Effects of Subchronic Exposure to Low Concentrations of Toluene on the Hypothalamo-Pituitary-Adrenal Gland Axis of Female Mice
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概要
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To examine the effects of subchronic exposure of low concentrations of toluene on the hypothalamo-pituitary-adrenal gland (HPA) axis, we analyzed the corticotropin releasing hormone (CRH) neurons in the hypothalamus and the adrenocorticotropic hormone (ACTH) cells in the pituitary gland of female mice, which inhaled toluene during 3 month period and were sensitized with ovalbumin (OVA). The data was culled using the immunocytochemical, morphometrical and RT-PCR methods. Adult female mice were divided into non allergy and allergy groups, which were sensitized with OVA. Each subgroup was further subdivided into control and 50ppm toluene exposure subgroups. The number of CRH-immunoreactive (ir) neurons and ACTH-ir cells, and ACTH-mRNA expression, were significantly elevated by toluene inhalation and OVA sensitization. Our results suggest that low concentrations of toluene and OVA sensitization act on the HPA axis as stressors.
- 社団法人大気環境学会の論文
- 2006-01-10
著者
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Kuwahara Sachi
Laboratory Of Veterinary Anatomy Graduate School Of Life And Environmental Sciences Osaka Prefecture
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Fujimaki Hidekazu
National Institute for Environmental Studies
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Kunugita Naoki
University of Occupational and Environmental Health
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Arashidani Keiichi
University of Occupational and Environmental Health
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Hori Hajime
University Of Occupational And Environmental Health
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Kunugita Naoki
Department Of Health Information Science School Of Health Sciences University Of Occupational And En
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Kunugita Naoki
Dept Radiation Biology &health
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SARI Dwi
Laboratory of Veterinary Anatomy, Graduate School of Life and Environmental Sciences, Osaka Prefectu
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TSUKAMOTO Yasuhiro
Laboratory of Veterinary Anatomy, Graduate School of Life and Environmental Sciences, Osaka Prefectu
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SASAKI Fumihiko
Laboratory of Veterinary Anatomy, Graduate School of Life and Environmental Sciences, Osaka Prefectu
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Sari Dwi
Laboratory Of Veterinary Anatomy Graduate School Of Life And Environmental Sciences Osaka Prefecture
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Sasaki Fumihiko
Laboratory Of Veterinary Anatomy Graduate School Of Life And Environmental Sciences Osaka Prefecture
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Fujimaki H
National Institute For Environmental Studies
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Arashidani K
University Of Occupational And Environmental Health
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Tsukamoto Yasuhiro
Laboratory Of Veterinary Anatomy Graduate School Of Life And Environmental Sciences Osaka Prefecture
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