Hyperexcitability of the Hippocampal CA1 and the Dentate Gyrus in Rats Subchronically Exposed to a Substitute for Chiorofluorocarbons, 1-Bromopropane Vapor

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概要

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• To investigate the effects on the central nervous system of subchronic exposure to 1-bromopropane (1-BP), which is a substitute for chlorofluorocarbons, we measured the hippocampal excitability of 1 -BP-treated rats electrophysiologically. Male Wistar rats were exposed to 1 -BP for 6-h in a day in an exposure chamber (1,500 ppm) for 4 wk. After the 1-, 3- and 4-wk inhalation, field excitatory postsynaptic potentials (fEPSPs), population spikes (PSs), fEPSP/spike (E/S) curve, paired-pulse profiles of fEPSP slopes and PS amplitudes recorded from CAl pyramidal neurons, and dentate granule cells of the hippocampal slice obtained from the rats were analyzed. In 1 -BP treated rats, E/S potentiation and a lower subthreshold of PSs were observed in the dentate gyrus (DG) after the 3 and 4-wk inhalation. Paired-pulse inhibition was reduced at 5-50 ms in the CAl and at 5-20 ms in the DG after all of the inhalation. These changes were not associated with paired-pulse inhibition of fEPSPs. In the DG, the paired-pulse inhibition at the short interpulse intervals in rats exposed to 1 -BP was pronounced by an application of A type gamma aminobutyric acid (GABA) receptor agonist pentobarbital. Impaired paired-pulse inhibition of granule cells at the short interpulse intervals was recovered after the application of N-methyl-D-aspartate (NMDA) type glutamate receptor antagonist DL-2- amino-5-phosphonopentanoic acid. Convulsing rats observed after the 4-wk inhalation exhibited multiple PSs in the DG, and their second component was abolished by an application of this antagonist. Inhalation of 1-BP increased the neuronal excitability in the hippocampal CAl and the DG. The hyperexcitability of the granule cells in the DG was at least due to an over-activation of NMDA receptors.

• 社団法人日本産業衛生学会の論文

著者

• ENDO Yutaka

  Department of Physiology, School of Medicine, University of Occupational and Environmental Health

• Endo Yutaka

  Department Of Cardiology Kokusai Shinzen Sougou Hospital

• Hori H

  Environmental Management School Of Health Sciences University Of Occupational And Environmental Heal

• Fueta Y

  The First Departments Of Medical Technology School Of Health Sciences University Of Occupational And

• Ishidao T

  Environmental Management School Of Health Sciences University Of Occupational And Environmental Heal

• Ishidao T

  School Of Health Sciences University Of Occupational Environmental Health

• FUETA Yukiko

  The First Departments of Medical Technology, School of Health Sciences, University of Occupational a

• ISHIDAO Toru

  Environmental Management, School of Health Sciences, University of Occupational and Environmental He

• ARASHIDANI Keiichi

  The Second Department of Environment Management, School of Health Sciences, University of Occupation

• HORI Hajime

  Environmental Management, School of Health Sciences, University of Occupational and Environmental He

• Arashidani K

  University Of Occupational And Environmental Health

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