Pharmacological Conversion of Persistent Atrial Fibrillation Into Sinus Rhythm With Oral Pilsicainide : Pilsicainide Suppression Trial for Persistent Atrial Fibrillation II(Clinical Investigation)
スポンサーリンク
概要
- 論文の詳細を見る
Background The present study was conducted to determine the antiarrhythmic efficacy and safety of oral pilsicainide, a class Ic antiarrhythmic drug, in patients with persistent atrial fibrillation (AF). Methods and Results One hundred and eight patients (mean age, 58.9 years) with AF lasting ≥48h and ≤6 months were randomized to receive pilsicainide 50mg t.i.d. (n=58) or placebo (n=50) for 2 weeks in a doubleblinded fashion. All patients underwent appropriate anticoagulation therapy with warfarin for ≥3 weeks prior to the study enrolment or after verification of the absence of left atrial thrombi by transesophageal echocardiography. After 2 weeks of treatment, an electrocardiogram was recorded to determine whether sinus rhythm was restored. Sinus rhythm was restored in 22.4% of patients treated with pilsicainide and in 2% treated with placebo (p=0.002). Cardioversion was less likely to occur with oral pilsicainide when the AF duration exceeded 2 months or if the left atrial diameter exceeded 45mm. There was no significant difference in the adverse cardiovascular event rate between the pilsicainide- and placebo-treated groups. One patient in the pilsicainide group developed an atrial flutter without any hemodynamic deterioration. Conclusion A 2-week oral administration of pilsicainide is well tolerated and moderately effective in converting persistent AF into sinus rhythm.
- 社団法人日本循環器学会の論文
- 2006-05-20
著者
-
ATARASHI Hirotsugu
Nippon Medical School
-
FUKATANI Masahiko
Chikamori Hospital
-
Fukunami Masatake
Osaka Prefectural Hospital
-
Atarashi Hirotsugu
Department Of Internal Medicine Nippon Medical School Tama-nagayama Hospital
-
Okishige Kaoru
Yokohama City Bay Red Cross Hospital
-
Kumagai Koichiro
Fukuoka University Hospital
-
Inoue Hiroshi
University of Toyama
-
KUMAGAI Koichiro
Heart Rhythm Center, Fukuoka Sanno Hospital
-
Kumagai Koichiro
Heart Rhythm Center Fukuoka Sanno Hospital
-
Inoue Hiroki
Department Of Chemistry Faculty Of Science Kyushu University
-
Iinuma Hiroyuki
Second Department Of Internal Medicine University Of Toyama
-
Fukunami Masatake
Osaka General Medical Center
-
Kumagai Koichiro
Fukuoka Sanno Hospital
関連論文
- Upregulation of Monocyte Tissue Factor Activity Is Significantly Associated With Low-Grade Chronic Inflammation and Insulin Resistance in Patients With Metabolic Syndrome
- Comparison of Antiarrhythmics Used in Patients With Paroxysmal Atrial Fibrillation : Subanalysis of J-RHYTHM Study
- Optimal Treatment Strategy for Patients With Paroxysmal Atrial Fibrillation : J-RHYTHM Study(Arrhythmia/Electrophysiology)
- Randomized Study of Angiotensin II Type 1 Receptor Blocker vs Dihydropiridine Calcium Antagonist for the Treatment of Paroxysmal Atrial Fibrillation in Patients With Hypertension : The J-RHYTHM II Study Design for the Investigation of Upstream Therapy for
- Investigation of the Optimal Treatment Strategy for Atrial Fibrillation in Japan : The J-RHYTHM (Japanese Rhythm Management Trial for Atrial Fibrillation) Study Design
- 3 Single Nucleotide Polymorphisms Associated with Drug Effectiveness on Long-term Mortality after Acute Myocardial Infarction(Plenary Session 7 (PL-7) (M) Genomic Approaches to Cardiovascular Diseases : Present and Future,Special Program,The 72nd Annual S
- 4 Minimally Elevated Troponin T at Chronic Phase can Identify Vulnerable Patients with Myocardial Infarction(New Evidence of Coronary Artery Disease-Pathogenesis, Diagnosis and Therapy, The 71st Annual Scientific Meeting of the Japanese Circulation Societ
- OJ-132 Impact of Atrial Flutter and Fibrillation on Development of Stroke after Acute Myocardial Infarction(Acute coronary syndrome, basic/clinical-2 (IHD) OJ22,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Ci
- Vasodilatory Effect of Subsequent Administration of Fasudil, a Rho-Kinase Inhibitor, Surpasses That of Nitroglycerin at the Concentric Coronary Stenosis in Patients With Stable Angina Pectoris
- Randomized Study of Angiotensin II Type 1 Receptor Blocker vs Dihydropiridine Calcium Antagonist for the Treatment of Paroxysmal Atrial Fibrillation in Patients With Hypertension : The J-RHYTHM II Study Design for the Investigation of Upstream Therapy for
- Rate Control and Quality of Life in Patients With Permanent Atrial Fibrillation : The Quality Of Life and Atrial Fibrillation (QOLAF) Study
- Pharmacological Conversion of Persistent Atrial Fibrillation Into Sinus Rhythm With Oral Pilsicainide : Pilsicainide Suppression Trial for Persistent Atrial Fibrillation II(Clinical Investigation)
- Double-Blind Placebo-Controlled Trial of Aprindine and Digoxin for the Prevention of Symptomatic Atrial Fibrillation
- PJ-501 Systolic Blood Pressure on Admission is Important Predictor of Response to CRT Therapy in Patients with Narrow QRS Complex(PJ084,CRT (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Impact of Drug Alteration to Maintain Rhythm Control in Paroxysmal Atrial Fibrillation : Subanalysis From J-RHYTHM Study
- Long-Term Effects of Box Isolation on Sympathovagal Balance in Atrial Fibrillation
- 0710 Catheter Ablation of Ventricular Tachycardia After Myocardial Infarction : Relationship of Endocardial Sinus Rhythm Late Potentials to the Reentry Circuit
- PE-529 Efficient Correction of Cardiac Abnormalities in Fabry Mice by AAV Type 8 Mediated Systemic Gene Transfer(PE089,Cardiomyopathy/Hypertrophy (Basic) (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-053 Statin Therapy Attenuates Monocyte Tumor Necrosis Factor Production and Improves Cardic Function and Long-term Prognosis in Chronic Heart Failure(OE09,Heart Failure (Treatment) 1 (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of
- Clinical Implication of T-Wave Morphology Analysis as a New Repolarization Descriptor
- PJ-374 A new Useful Index of Mechanical Dyssynchrony by Gated SPECT in Cardiac Resynchronization Therapy(Heart failure, clinical-10, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- -0057-DETERMINATIONS OF THE GENETIC DISORDERS OF FABRY'S DISEASE
- Dose-Response Effects of Bepridil in Patients With Persistent Atrial Fibrillation Monitored With Transtelephonic Electrocardiograms : A Multicenter, Randomized, Placebo-Controlled, Double-Blind Study (J-BAF Study)
- Utility of rapid D-dimer measurement for screening of acute cardiovascular disease in the emergency setting
- PJ-631 Clinical Significance of Serial Studies of Cardiac I-123 Metaiodobenzylguanidine Imaging for Prediction of Sudden Death in Chronic Heart Failure Patients(PJ106,Nuclear Cardiology (Others) (I),Poster Session (Japanese),The 73rd Annual Scientific Mee
- PJ-152 Usefulness of Cardiac l-123metaiodobenzylguanidine Imaging for Prediction of Cardiac Death in Chronic Heart Failure With/Without Renal Dysfunction : A Prospective Syudy(Nuclear cardiology(07)(I),Poster Session(Japanese),The 72nd Annual Scientific M
- PJ-148 Prevention of Contrast-Induced Nephropathy With Sodium Bicarbonate and Long-Term Clinical Outcomes in Patients Undergoing an Emergent Coronary Procedure(Kidney/Renal circulation(05)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of
- OJ-173 Prognostic Value of Cardiac I-123 metaiodobenzylguanidine Imaging in Chronic Heart Failure : A Prospective Comparative Study With a Variety of ECG Parameters(Nuclear cardiology(02)(I),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting
- Associations Between Augmentation Index and Severity of Atheroma or Aortic Stiffness of the Descending Thoracic Aorta by Transesophageal Echocardiography
- PJ-158 Characteristics of the Conduction of the Left Atrium in Atrial Fibrillation Using Non-contact Mapping(PJ027,Arrhythmia, Others (Clinical/Pathophysiology) 2 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation
- OJ-076 Should Termination of Atrial Fibrillation be the Endpoint for Ablation of Persistent or Chronic Atrial Fibrillation?(OJ13,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 1 (A),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The
- OE-270 Characteristics of Induced Atrial Tachyarrhythmias and CFAE distribution after Box Isolation(OE46,Atrial Fibrillation/Supraventricular Arrhythmia: Diagnosis 3 (A),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circul
- OE-042 Long-Term Effects of Box Isolation on Atrial Sympathovagal Balance in Atrial Fibrillation(OE07,Atrial Fibrillation/Supraventricular Arrhythmia: diagnosis 2 (A),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulati
- PJ-609 Usefulness of Non-contact Mapping for Catheter Ablation of Atrial Tachycardia(Arrhythmia, therapy(26)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- P418 EXPERIMENTAL STUDY OF MULTI-SITE SEQUENTIAL VENTRICULAR PACING FOR THE SUPPRESSION OF VENTRICULAR FIBRILLATION
- Characteristics of a New Repolarization Descriptor Substituted for T-Wave Morphology Analysis in Patients With Cardiomyopathy and Myocardial Infarction
- HEMODYNAMIC COMPARISON STUDY OF CARDIAC FUNCTION BEFORE AND AFTER RADIOFREQUENCY CATHETER ABLATION IN PATIENTS WITH WPW SYNDROME.
- -0344-PATHOLOGICAL CHANGES IN THE MICROTUBULE NETWORKS IN THE HUMAN CARDIOMYOPATHY : MYOCARDIAL BIOPSY STUDY
- PJ-401 Comparison of Upstream Therapies for Paroxysmal Atrial Fibrillation in Patients without Overt Heart Diseases(Arrhythmia, therapy(20)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-483 The Incidence and Characteristics of Focal Atrial Tachycardia in Patients Following Open-Heart Surgery(Arrhythmia, diagnosis/Pathophysiology/EPS(09)(A),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-113 The Differential Overdrive Pacing : A Novel Diagnostic Method of Atrial Tachycardia Irrespective of Retrograde VA Conduction(Arrhythmia, diagnosis/pathophysiology/EPS-08, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-111 Post-operative Atrial Tachycardia Following Mitral Surgery via the Superior Transseptal Approach(Arrhythmia, diagnosis/pathophysiology/EPS-07, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 7 A Proposal of Cultivating National and Prospective Observational Study to Establish Evidence-based Guidelines for Treating Patients with AMI(Symposium 18 (SY-18) (H) How can we Make the Best Use of Japanese Evidences for Future Guidelines,Special Progra
- PE-139 Mapping-guided Ablation of the Cavotricuspid Isthmus : A Novel Simplified Approach for Radio frequency Catheter Ablation of Isthmus-dependent Atrial Flutter(Arrhythmia, therapy-9 (A) PE24,Poster Session (English),The 70th Anniversary Annual Scienti
- DETECTION OF REGION OF INFECTIOUS ENDOCARDITIS USING INDUM-111 OXINE PLATELET SCINTIGRAPHY : Infective Endocarditis : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -330-THE INCIDENCE OF LEFT ATRIAL THROMBI AND EFFECTS OF ANTICOAGULANT THERAPY IN PATIENTS WITH RHEUMATIC MITRAL STENOSIS : ASSESSMENT WITH INDIUM-111 PLATELET SCINTIGRAPHY
- PE-397 Inflammatory Reaction Plays Significant Roles in the Pathogenesis and Instability of Vasospastic Angina(Chronic coronary heart disease/Remodeling-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Relationship between subjective symptoms and trans-telephonic ECG findings in patients with symptomatic paroxysmal atrial fibrillation and flutter
- Dose-Response Effect of Flecainide in Patients With Symptomatic Paroxysmal Atrial Fibrillation and/or Flutter Monitored With Trans-Telephonic Electrocardiography : A Multicenter, Placebo-Controlled, Double-Blind Trial
- PJ-025 Clinical Significance of Electrocardiogram Pattern in Patients with Bundle-Branch Block(PJ004,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 8 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-090 Differential Effect of Lipid Ratios on Long-term Prognosis of Patients with Acute Coronary Syndrome Underwent Successful Percutanoues Coronary Intervention(PE015,ACS/AMI (Clinical/Pathophysiology) 1 (IHD),Poster Session (English),The 73rd Annual Sc
- OE-263 Statin Therapy Improves Long-term Prognosis Associated with Reduction of Inflammation in Patients with Vasospastic Angina(OE45,Angina Pectoris (Clinical, Basic) (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Ci
- FRS-083 Statin Therapy Reduces Cardiac Events in Acute Coronary Syndrome Patients with Chronic Kidney Disease(FRS17,Novel Approaches to Treatment of CAD (IHD),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulati
- PE-248 The Ratio of Low-density Lipoprotein Cholesterol to High-density Lipoprotein Cholesterol Predicts Adverse Outcomes in Patients with Acute Myocardial Infarction(Acute myocardial infarction, clinical(pathophysiology)(02)(IHD),Poster Session(English),
- PE-069 Metabolic Syndrome Increases the Risk of Mortality in Patients with Acute Coronary Syndromes Underwent Successful Percutaneous Coronary Intervention(Diabetes/Obesity/Metabolic syndrome(04)(H),Poster Session(English),The 72nd Annual Scientific Meeti
- OE-247 Metabolic Syndrome Increases the Risks of Cardiac Events Associated with Insulin Resistance in Patients with Vasospastic Angina(Chronic coronary heart disease/Remodeling(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the
- DPE-005 Upregulation of Monocyte Tissue Factor Activity of Metabolic Syndrome Contributes to the Pathogenesis of Acute Coronary Syndrome(DPE01,Metabolic Syndrome (H),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circu
- OE-314 Impact of Myocardial Perfusion and Metabolism for Left Ventricular Systolic Function and Synchrony(OE53,Nuclear Cardiology (Coronary, Myocardium) 2 (I),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Socie
- OE-016 Impact of Chronic Kidney Disease on Long-term Prognosis of Acute Coronary Syndromes Successfully Treated with Percutaneous Coronary Intervention(Acute coronary syndrome, basic/clinical(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific
- 4 Insulin Resistance and Subclinical Inflammation Play Significant Roles in the Pathogenesis and Instability of Vasospastic Angina(Symposium 2 (SY-02) (IHD) Coronary Spasm Revisited,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circul
- Visual Assessment of the Myocardial Tissues during the Application of the Cryofreezing Energy through the Catheter Using Intracardiac Echocardiography
- OE-123 Plasma Level of Stem Cell Factor in Patients with Various Degrees of Chronic Heart Failure.(Heart failure, clinical(02)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-096 Utility of Rapid D-dimmer Measurement for Screening of Superacute Phase of Acute Coronary Syndrome in Emergency Setting(Acute coronary syndrome, basic/clinical-5, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-009 Exercise Stress Myocardial Perfusion Scintigraphy Predicts Cardiac Events in Patients with Vasospastic Angina(Angina pectoris, basic/clinical-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Changes in Resting Electrocardiogram in Subjects 10 Years after Minor Abnormal Findings
- Effects of Music Therapy on Heart Rate Variability in Elderly Patients with Cerebral Vascular Disease and Dementia
- OE-257 Peak White Blood Cell Count and Fasting Glucose are Independent Predictors of Left Ventricular Remodeling in Reperfused Acute Myocardial Infarction(Acute myocardial infarction, clinical (diagnosis/treatment)-1, The 71st Annual Scientific Meeting of
- OE-254 Peak White Blood Cell Count and Fasting Glucose are Independent Predictors of Cardiac Events in Patients with Acute Myocardial Infarction(Acute myocardial infarction, clinical (pathophysiology)-1, The 71st Annual Scientific Meeting of the Japanese
- PE-009 Statin Therapy Reduces Atherosclerotic Plaque Burden and Improves Prognosis in Patients with Acute Coronary Syndromes(Acute myocardial infarction, clinical (diagnosis/treatment)-5 (IHD) PE2,Poster Session (English),The 70th Anniversary Annual Scien
- Comparative Study between the Endocardial and Epicardial Implantation of the Biventricular Pacemaker for the Patients with Dilated Cardiomyopathy
- Enhanced-Density Mapping Regarding the Retrograde Conduction at the Koch's Triangle Using Electroanatomical Mapping System (CARTO)
- OE-035 Metabolic Syndrome Increases the Incidence of Heart Failure Associated with Subclinical Inflammation in Patients with Acute Coronary Syndromes(Heart failure, clinical-01, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-016 Utility of Rapid D-dimer Measurement for Screening of Acute Cardiovascular Disease in Emergency Setting(Emergency care-1 (H) OE3,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- OE-004 Metabolic Syndrome Increases Atherosclerotic Plaque Burden and Cardiac Events Associated with Inflammation in Patients with Acute Coronary Syndromes(Acute coronary syndrome, basic/clinical-1 (IHD) OE1,Oral Presentation (English),The 70th Anniversar
- 3 Na channel blocker challenge test is still controversial to predict the prognosis(Do patients with drug-induced Brugada type ECG have poor prognosis?,Controversy 6 (C-6) (A),Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation
- A New Electrocardiographic Criteria for the Symptomatic Brugada Syndrome
- OJ-014 Parasympathetic Stimulation by Music Attenuates Heart Failure Events, Plasma Interleukin-6(IL-6) and Epinephrine Levels in Elderly Patients(Autonomic nervous system(02)(H),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japane
- A Novel Noninvasive Method for Estimating Atrial Refractoriness
- OE-165 Upregulation of Monocyte Chemokine Production by C-Reactive Protein Contributes to the Exacerbation of Chronic Heart Failure(Heart failure, clinical-1 (M) OE28,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japane
- Fast Fourier transform (FFT) analysis of the effects of epalrestat, an aldose reductase inhibitor, on autonomic function in diabetic patients
- OJ-327 Music Therapy is Useful for Cardiac Autonomic Nerve Functions in Octogenarian Patients with Cerebral Vascular Disorders, Dementia and Heart Failure(Autonomic nervous system-2 (H) OJ55,Oral Presentation (Japanese),The 70th Anniversary Annual Scienti
- PE-135 Effects of Music Therapy on Autonomic Nerve Activities, Heart Failure Events and Plasma Proinflammatory Cytokine Levels in Elderly Patients(Autonomic nervous system-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Guidelines for Pharmacotherapy of Atrial Fibrillation (JCS 2008) : Digest Version
- Angiotensin-Converting Enzyme Inhibitor Therapy Inhibits the Progression From Paroxysmal Atrial Fibrillation to Chronic Atrial Fibrillation
- OJ-383 Importance of RAS Inhibition in the Management of Paroxysmal Atrial Fibrillation in Patients with Metabolic Syndrome(Arrhythmia, therapy-6 (A) OJ64,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulat
- AUTONOMIC NEURAL MODULATION OF ATRIOVENTRICULAR CONDUCTION TIME ANALYZED BY SPECTRAL ANALYSIS
- PJ-796 Statins Exclusively Provide a Beneficial Effect in Treatment of Chronic Heart Failure Patients with Diabetes Mellitus or Impaired Fasting Glucose(Heart failure, clinical-18, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-470 Metabolic Syndrome Influences the Effect of ACE Inhibitors on Morbidity and Mortality in Patients with Chronic Heart Failure(Heart failure, clinical-7 (M) PE79,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese
- Atypical Exercise Stress Myocardial Perfusion SPECT Imaging in a Patient With Effort Angina Pectoris
- Investigation of optimal anticoagulation strategy for stroke prevention in Japanese patients with atrial fibrillation : The J-RHYTHM Registry study design
- Present Status of Anticoagulation Treatment in Japanese Patients With Atrial Fibrillation : A Report From the J-RHYTHM Registry
- Antithrombotic Therapy in Atrial Fibrillation : Evaluation and Positioning of New Oral Anticoagulant Agents
- Inflammation and Atrial Fibrillation
- Effects of Statin Therapy on the Production of Monocyte Pro-Inflammatory Cytokines, Cardiac Function, and Long-Term Prognosis in Chronic Heart Failure Patients With Dyslipidemia
- Predictors Which Can Differentiate the Timing of Recurrence of Atrial Fibrillation between at Short-Term and at Long-Term after the Catheter Ablation
- Target International Normalized Ratio Values for Preventing Thromboembolic and Hemorrhagic Events in Japanese Patients With Non-Valvular Atrial Fibrillation:– Results of the J-RHYTHM Registry –
- Three-Minute ECG Recording and Arrhythmia Detectionin the Evaluation and Promotion of Health
- Association between Serum Uric Acid and Change in Estimated Glomerular Filtration Rate after 10 years
- Thromboembolic Events in Paroxysmal vs. Permanent Non-Valvular Atrial Fibrillation:– Subanalysis of the J-RHYTHM Registry –
- Target International Normalized Ratio Values for Preventing Thromboembolic and Hemorrhagic Events in Japanese Patients With Non-Valvular Atrial Fibrillation : Results of the J-RHYTHM Registry