抗原刺激CD4^+CD25^+調節性T細胞による皮膚拒絶反応の阻害 : in vitroとin vivoにおける研究

概要

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In the present studies, we examined the role of regulatory T cells in developing strategies to achieve skin graft-specific tolerance and explored the immune characteristic of Treg cells and the main mechanisms through which inducing transplantation tolerance. The 5×10^4 Treg could inhibit the MLR obviously, and the effect of the Treg to the MLR is dose dependent. The suppression rate of Treg to response T cell from the donor was higher than control group that came from the non-donor, indicating that the suppression of Treg to response T cell was antigen specific. SR of Treg in co-culture was greater than that in separate culture, inferring that CD4^+CD25^+ Treg cells exerted their suppressive effects on effector T cells through cell to cell contact mechanism and cytokines secretion mechanism. In the group 1×10^5 Treg injected, the mean survive time of skin grafts from C57BL/6 mice was obviously longer than the control group. These data suggest that antigen-primed CD^4+CD25^+Treg are effective therapeutic tool to prevent skin allograft rejection.
聖隷クリストファー大学の論文
2004-03-31