実験的大腸癌におけるマクロファージ分布の系統差

概要

論文の詳細を見る
Colorectal cancer (CRC) is one of the most common forms of malignancy in humans. Patients with long-standing ulcerative colitis (UC) have an increased risk for developing CRC compared to the general population. For investigation of the mechanisms and prevention of UC, and UC-related CRC, we first induced UC by DSS and then induced CRC by DMH. It took only 3 months to found the CRC model in Wister rats. The important similarities of the model may be seen in the clinical and pathological findings in animals and patients with CRC developing from UC. It is especially suited to the study of UC and CRC. In this study the mean percent of ED1, and ED3 positive macrophages in Wistar rats was higher than that in DA and Lewis rats (p < 0.05). The mean percent of Marl, and Mar3 positive macrophages in DA and Lewis rats was higher than that in Wistar rats (p < 0.05). These results suggested that the existence of four types of macrophages may play an important role in inducing colitis and rectal cancer. Furthermore, the mechanisms of strain difference in the experimental models are discussed.
聖隷クリストファー大学の論文
2003-03-31