Articular Involvement of SLE and its Clinical Significance

概要

論文の詳細を見る
Articular symptoms were observed in 67 of 81 patients (83%) with systemic lupus erythematosus (SLE) at different times during the course of their illness and in 37 cases (46%) as initial symptoms. Fourty four patients (54%) complained arthritis. The majority of these were migratory, while some arthritis lesions persisted for 4 weeks or longer (10 cases) and some others (5 cases) were deforming. Almost all peripheral joints were involved, knees and hands being most frequently affected. The radiographic observation revealed limited incidence of narrowing of joint spaces (4 cases) and erosion (4 cases) in patients with arthritis. Three putative cases of "overlap syndrome" with co-existing rheumatoid arthritis (RA) were found : all had late onset and long duration. It therefore seems necessary to monitor closely the progress of articular symptoms associated with late onset and/or long duration of SLE. Patients presenting with arthritis had significantly higher incidence of morning stiffness and serositis, but much less renal morbidity. On the contrary, absence of articular symptoms was related to the significantly higher incidence of serious renal complications such as nephrotic syndrome and/or renal failure as well as with increased mortality. Therefore, understanding of the arthritis presented by SLE patients seems essential to ensure proper choice of therapy and accurate prognosis.
北里大学の論文
1985-06-30