自由行動下におけるヒツジ咀嚼筋活動に及ぼす中枢性筋弛緩薬 (NK433) の影響

概要

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Muscle relaxants are commonly used in the treatment of masticatory muscle dysfunction, A muscle relaxant drug NK433 (R-(-)-2-methyl-3-pyrrolidino-1- (4-trifluoromethylphenyl) -1-propanone hydrochloride) which is related to the benzodiazepine group is being developed in Japan. The relaxant effects of this medication were investigated on masticatory movement in this study. Four sheep who had had unilateral condylectomy performed were studied. They were administered with the recommended oral dose for humans of NK433 in a nasal gastric tube to the stomach. Electromyographic (EMG) activity was recorded before dosage and then at intervals of I O minutes for up to two hours following dosing. It was founded that the amplitude of muscle activities decreased after drug administration to post condylectomy sheep. It was noted that the rhythmically chew and masticatory frequency on the constant feed was not influenced significantly by the drug administration, This study shows that the relaxant drug NK433 dose have an effect on sheep mastication. This effect would be to reduce muscle activity and thus would support the view that this may be beneficial in the treatment of muscular dysfunction.
九州保健福祉大学の論文
2004-03-25