A Bayesian Approach to Identifying Rheumatoid Arthritis Disease Gene

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概要

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• Rheumatoid arthritis (RA) is a late-onset polygenic disease caused by both genetic and environmental factors. Using microsatellite marker and sib-pair linkage study, we have previously identified 3 principal chromosome regions of linkage designated as RA1, RA2 and RA3, and the disease susceptible gene of interest is currently being identified by us. We have now searched a mathematical method to prove if the gene of interest is indeed genetically responsible for the disease or not. We have adopted a method to calculate the posterior probability of the proband in a family of RA from prior probabilities by using Bayes' theorem. We found by performing some numerical simulations that the posterior probability depended strongly on the amount of affected relatives with the information of genotypes.

• 神戸大学の論文
• 2000-12-27

著者

• Tsukamoto Yasuo

  Faculty Of Health Science Kobe University School Of Medicine

• Shiozawa Shunichi

  Faculty Of Health Science Kobe University School Of Medicine

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