A Computer Algorithm for the Standardization of Marker Size Obtained by Electrophoresis for Microsatellite Marker Analysis
スポンサーリンク
概要
- 論文の詳細を見る
We have applied the microsatellite marker anaysis to identify the gene loci that predispose to rheumatoid arthritis (RA). During execution of an improved computational algorithm after Holmans & Clayton, which is able to estimate the missing marker genotypes of parents by incorporating one unaffected sibling into an affected sib pair, we encountered the problem that the sizes of microsatellite markers obtained by electrophoresis were not always concentrated strictly around the expected, two-base distant, values. To overcome this problem, we have devised a new algorithm to standardize the size of marker alleles for automatic computational processing. Three feasible markers were identified under the criterion of the lod score being more than the prescribed level 3, which is generally used for the linkage analysis.
- 神戸大学の論文
- 1997-12-26
著者
-
Tsukamoto Yasuo
Faculty Of Health Science Kobe University School Of Medicine
-
Shiozawa Shunichi
Faculty Of Health Science Kobe University School Of Medicine
関連論文
- Abnormally Shaped-Polyclonal Hypergammaglobulinemia in Pulmonary Fibrosis, Splenomegaly, Sjogren Syndrome and Reactive Lymphadenopathy
- A Mathematical Model for the Proliferation and Death of T Cells
- Finite Element Analysis for the Stress Distribution in Atherosclerotic Vessels by Using Personal Computer
- A Simulation Study of Antibody Production by T and B Cells
- A Computer Algorithm for the Standardization of Marker Size Obtained by Electrophoresis for Microsatellite Marker Analysis
- A Bayesian Approach to Identifying Rheumatoid Arthritis Disease Gene
- Increased c-Fos/activator protein-1 confers resistance against anergy induction on antigen-specific T cell