A Simulation Study of Antibody Production by T and B Cells

概要

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The immune response is triggered subject to the dose of antigen which invaded into body space. The antigen is recognized and engulfed by macrophages and then it is degraded into small peptides. The degraded antigen peptide is presented to helper T cells in the context of MHC (major histocompatibility complex) molecule to the surface of antigen-presenting cell (APC) such as macrophages. When T cells recognize antigen in the context of MHC, Tho cell is activated and differentiate into Th2 cell. Th2 cell then helps B cells to proliferate and differentiate finally into antibody secreting cells. B cells secrete antigen specific IgM and IgG antibodies which interact with antigen. When Th2 and B cells are activated, the process of activation induced cell death (AICD) will start. This process is regarded as several biochemical chain reactions associated with strong proliferation of T and B cells. From this standpoint, we proposed a simulation model representing the Michaelis-Menten equation for biochemical dynamics in association with exponential growth and death of T and B cells. This type of mathematical analysis will explain mutual interaction among APC, T cell and B cell effectively as exemplified by this model.
神戸大学の論文
1999-12-26