Progressive Central Nervous System Metastases in Responder Patients for Outside Central Nervous System Metastases on Trastuzumab-Based Therapy : Report of Two Cases of Refractory Breast Cancer
スポンサーリンク
概要
- 論文の詳細を見る
We report two cases of central nervous system (CNS) metastases during systemic response to trastuzumab in combination with chemotherapy for refractory breast cancer. The patients responded to trastuzumab in combination with chemotherapy. During combination treatment, the patients developed cerebellar metastases. A follow-up computed tomography scan revealed that their diseases continued to respond outside the CNS. These cases suggest that the failure of trastuzumab to cross the blood-brain barrier may compromise its overall effectiveness and raises the possibility that CNS metastasis may become clinically more significant in patients receiving antibody-based therapies, including patients responding to therapy outside the CNS. Additionally, repeated stereotactic radiosurgery as gammaknife combination therapy synchronously with systematic trastuzumab-based therapy was useful for the treatment of metastatic breast carcinoma.
- 広島大学の論文
著者
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Saeki Toshiaki
埼玉医科大学国際医療センター 乳腺腫瘍科
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Saeki Toshiaki
Department Of Breast Oncology Saitama Medical University International Medical Center
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AOGI Kenjiro
Department of Clinical Research and Surgery, Shikoku Cancer Center
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OKITA Riki
Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima Un
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TAKASHIMA Shigemitsu
Department of Clinical Research and Surgery, Shikoku Cancer Center
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OHSUMI Shozo
Department of Surgery, National Hospital Organization Shikoku Cancer Center
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Takashima Shigemitsu
Department Of Clinical Research And Surgery National Shikoku Cancer Center
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Saeki Toshiaki
Department Of Breast Oncology Saitama International Medical Center Saitama Medical University
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Saeki Toshiaki
Department Of Surgery National Shikoku Cancer Center Hospital
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Okita Riki
Department Of General Thoracic Surgery Hiroshima University Hospital
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Takashima Shigemitsu
The Departments Of Surgery The Shikoku Cancer Center Hospital
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Ohsumi Shozo
Department Of Breast Surgery National Hospital Organization Shikoku Cancer Center
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Ohsumi Shozo
Department Of Breast Oncology National Hospital Organization Shikoku Cancer Center
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Ohsumi Shozo
The Departments Of Surgery The Shikoku Cancer Center Hospital
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Takashima Shigemitsu
Department Of Breast Oncology National Hospital Organization Shikoku Cancer Center
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Okita Riki
Department Of Surgical Oncology Research Institute For Radiation Biology And Medicine Hiroshima Univ
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Aogi Kenjiro
Department Of Breast Oncology National Hospital Organization Shikoku Cancer Center
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Saeki Toshiaki
Department Of Breast Oncology International Medical Center Saitama Medical University
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