3 Crohn病の治療の進歩 : 内科的立場から(シンポジウム炎症性腸疾患の病因と治療の進歩)(第578回新潟医学会)

概要

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Medical treatment for Crohn's disease includes enteral nutrition (EN), various drugs, and diet. Especially in Japan. EN is recommended as primary therapy for Crohn's disease. But the longterm effect of EN has not been proven by controlled trial, because long-standing clinical trials are too difficult. Retrospective study in my institute revealed effectiveness of long-term home enteralnutrition (HEN). The cumulative non-operative rate from onset in HEN group (n=31) were 100% in 5 year, 77.5% in 10 year, and 65.5% in 15 year, compared with 71.7%, 26.4%, and 17.6%, respectively, in non-HEN group (n=17). Recombinant anti-tumor necrosis factor a antibody (infliximab) is new immuno-modulation therapy for Crohn's disease. But duration of the effects are known so restrictive. Most effective usage of infliximab have to be determined in the near future.
新潟大学の論文