微小流路における血球の流動特性観察システムの開発(S03-1 制御と情報・生体への応用(1),S03 制御と情報・生体への応用)

概要

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Neutrophils retain in pulmonary capillaries causing 40- to 80-fold higher concentration than in systemic large vessels in normal lungs. The highly concentrated neutrophils are effectively recruited to inflammations for the host defense. Therefore, it is important to know the flow characteristics of neutrophils in pulmonary capillary bed for the understanding of the immune system in lungs. In previous studies, flow of a neutrophil through a narrow capillary was investigated numerically to develop a mathematical model. It is indispensable to evaluate the accuracy of the model. In this research, an observation system of flow of blood cells in microchannels is constructed, and the cell velocities are measured. Neutrophils don't pass through the channel under the pressure control. Erythrocytes pass through it under the flow rate control, and their velocities are measured to show that the velocity profile along their loci varies with the cell orientation entering the channel.
2004-09-04