毛細血管ネットワークにおける好中球の流動シミュレーション(S03-1 制御と情報・生体への応用(1),S03 制御と情報・生体への応用)

概要

論文の詳細を見る
Neutrophils are known as the most popular cells in leukocytes. They retain in pulmonary capillaries even in normal lungs causing 40- to 80-fold higher concentration than in systemic large vessels. The highly concentrated neutrophils are recruited to inflammations for the host defense. Therefore, it is essential to know their flow characteristics in the pulmonary capillary bed for the understanding of the immune system in lungs. For that purpose, authors have investigated the flow of a neutrophil in single capillary segment, and developed a mathematical model to simulate the flow of neutrophils in a capillary network. In this research, effect of the cell stiffness on the distribution of transit time of the cells is investigated. The result shows that the median of the transit times is longer than the average value for all the three levels of cell stiffness.
2004-09-04