特集「肺」導入として,肺線維症・肺気腫におけるリモデリング(<特集>肺)

概要

論文の詳細を見る
"Remodeling" means the new formation of the different tissue structure and function in association with the previous destruction of the basic architecture of the organ. In interstitial pneumonia (IP), usual IP (UIP) and nonspecific IP show the pulmonary structural remodeling due to the coalescence of alveolar walls by intraalveolar fibrosis. Especially in UIP, the process to form honeycombing is a loss of alveoli and alveolar bronchiolization, and is irreversible. In cryptogenic organizing pneumonia, polyp-like intraalveolar fibrosis does not coalesce alveolar walls. Emphysema shows the structural remodeling of the alveoli with the overextension of the alveolar walls resulting from the degradation of their elastic fibers. Although the new elastogenesis is observed in emphysema, the structure of these fibers is not fibrous and the localization is abnormal. New deposited elastin in emphysema is not effective to show the elasticity in the alveoli.
日本結合組織学会の論文
2002-09-25