Epithelial and Stromal Changes after Castration and Testosterone Treatment in Rat Prostate

概要

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The effects of glycosaminoglycans(GAGs)and androgen on the prostatic growth were studied using tissue from intact controls, castrated, and androgen-treated castrated rats. Biochemical analysis of glycosaminoglycans revealed increased dermatan sulfate(DS)and haparan sulfate(HS)in the ventral lobe of the prostate after castration. After testosterone propionate(TP)treatment, chondroitin 4-sulfate(CS4)and chondroitin 6-sulfate(CS6)increased. An immunohistochemical observation revealed different inten-sities of glycosaminoglycans such as chondroitin sulfate(CS), DS and HS after castration and TP treatment. Morphologically, after castration, indentation of the nuclear membrane was remarkable in the epithelial cells, and apoptotic cells were encountered in the lamellated epithelial cell layer combined with the irregular thickening of the basal lamina and atrophic stromal cells. After androgen administration in castrated rats, the prostatic epithelial cells increased in size and the stromal volume decreased. The effects of androgens upon prostatic growth may depend on the relationship between the epithelium and stromal components mediated by not only growth factors but also glycosaminoglycans.
日本結合組織学会の論文
2000-03-25