Expression and Localization of Lumican in the Ischemic and Reperfused Rat Heart
スポンサーリンク
概要
- 論文の詳細を見る
Lumican belongs to the small leucine-rich proteoglycan family and has an important role in the regulation of corneal and dermal collagen fiber assembly. Recently, lumican mRNA was found in the heart and its high expression was reported during wound healing of the cornea. In the present study, the expression and role of lumican in fibrosis of an ischemic and reperfused rat heart were examined. The expression level of lumican mRNA increased in the ischemic and reperfused rat heart and was highest on the fourth week. Lumican protein existed in the forms of core protein and proteoglycan in the control rat heart. The amount of lumican in the form of proteoglycan increased, and that as the form glycoprotein was newly detected in the ischemic and reperfused rat heart on the fourth week. In the control heart, lumican was weakly expressed in the collagen fibers of the perivascular area, but it was expressed strongly in many capillary endothelial cells in the ischemic lesion on day 1. After 3 days, lumican was localized in collagen fibers and in the fibroblasts of fibrotic lesions. A few myocardial cells close to the ischemic lesion expressed lumican mRNA. Lumican is considered to play an important role in the fibrillogenesis of the ischemic and reperfused rat heart.
- 社団法人日本循環器学会の論文
- 2001-04-20
著者
-
Asano G
Nippon Medical School
-
Asano Goro
Department Of Pathology Nippon Medical School
-
Takashi En
日本医科大学 病理
-
En Takashi
Dept. Of Pathology Nippon Medical School
-
ISHIWATA Toshiyuki
Department of Pathology II, Nippon Medical School
-
Xu Guang
Department of Pathology, Nippon Medical School
-
Xu Guang
Dept. of Pathology, Nippon Medical School
-
Ishiwata T
Department Of Pathology Nippon Medical School
-
Ishiwata Toshiyuki
Department Of Pathology Ii Nippon Medical School
-
Ishiwata Toshiyuki
Department Of Integrative Pathology (second Department Of Pathology) Graduate School Of Medicine Nip
-
Xu Guang
Dept. Of Pathology Nippon Medical School
-
Baba Hideyuki
Department of Pathology, Nippon Medical School
-
En Takashi
Department of Pathology, Nippon Medical School
-
Takashi En
Department Of Integrative Pathology Nippon Medical School
-
Baba Hideyuki
Department Of Pathology Nippon Medical School
-
Xu G
Department Of Electrical And Electronic Engineering Faculty Of Engineering Ibaraki University
-
Asano Goro
The Department Of Pathology Nippon Medical School
-
Xu G
日本医科大学 病理
-
Ishiwata Toshiyuki
Department Of Pathology Integrative Ontological Pathology Nippon Medical School
-
Xu Guang
Department Of Electrical And Electronic Engineering Faculty Of Engineering Ibaraki University
-
En Takashi
Department of Integrative Pathology, Nippon Medical School
関連論文
- 尿中塩基性線維芽細胞増殖因子(bFGF/FGF-2) (広範囲 血液・尿化学検査 免疫学的検査(第7版・4)その数値をどう読むか) -- (腫瘍マーカー)
- 内分泌細胞含有大腸低分化腺癌におけるVEGF発現の意義(第105回日本外科学会定期学術集会)
- HP-148-1 ヒト膵癌におけるSTAT 5の発現,活性化についての検討(膵(基礎研究),ハイブリッドポスター,第109回日本外科学会定期学術集会)
- P-2-389 膵癌におけるNestinの発現の検討(胆・膵 研究,一般演題(ポスター),第63回日本消化器外科学会総会)
- O-1-105 Neuropilin-1の膵癌における生物学的意義,そのintegrin beta1との関連について(胆・膵 研究4,一般演題(口演),第63回日本消化器外科学会総会)
- HP-150-1 消化管癌におけるkeratinocyte growth factor receptor (KGFR)の発現と局在の意義(基礎研究2,ハイブリッドポスター,第109回日本外科学会定期学術集会)
- 胃癌におけるkeratinocyte growth factor receptor (KGFR)とKGFの発現および神経内分泌細胞のはたす役割
- 食道癌におけるKeratinocyte growth factor receptor (KGFR)の発現と局在
- DP-057-3 直腸悪性黒色腫におけるc-kitの関与(第107回日本外科学会定期学術集会)
- 進行大腸癌におけるルミカンの発現意義
- 大腸癌肝転移症例におけるLumicanの発現
- O-2-208 消化管癌におけるKeratinocyte growth factor (KGF)とreceptorの役割(診断,一般演題(口演),第62回日本消化器外科学会定期学術総会)
- DP-137-6 消化管癌のtumorigenesisにおけるKeratinocyte growth factor receptor(KGFR)とそのligandsの役割(第107回日本外科学会定期学術集会)
- 食道癌における Keratinocyte growth receptor (KGFR/FGFR2IIIb) の発現と分化の関連性(食道・胃・十二指腸2, 第60回日本消化器外科学会総会)
- PPS-1-245 大腸癌における線維芽細胞増殖因子受容体の発現とその意義(大腸分子生物1)
- SF-052-3 Keratinocyte growth factor receptor (KGFR)遺伝子発現の抑制による大腸癌細胞の増殖抑制効果
- SF-052-1 大腸癌におけるkeratinocyte growth factor receptor (KGFR/FGFR 2IIIb)の発現と局在
- PP-2-354 mRNAレベルでの線維芽細胞増殖因子阻害による大腸癌増殖制御の可能性
- DP-145-2 大腸低分化腺癌の免疫組織学的検討(第108回日本外科学会定期学術集会)
- O-2-98 胃癌におけるlumicanの発現(胃 研究3,一般演題(口演),第63回日本消化器外科学会総会)
- DP-119-2 大腸癌組織におけるnestin陽性微小血管の意義と予後との関連(第107回日本外科学会定期学術集会)
- 関節リウマチにおける HGF-activator, HGFおよびC-Metの役割
- PPS-2-149 食道癌における血管新生関連蛋白の発現と臨床病理学的因子との検討(食道分子生物3)
- PS-106-3 ヒト胃癌におけるルミカンの発現と腸上皮化生
- P1-164 FGFR2 IIIcは子宮頸癌を増殖させる(Group20 子宮頸部悪性腫瘍1,一般演題,第62回日本産科婦人科学会学術講演会)
- P3-17 子宮頸癌発生過程におけるFGFR2IIIcの発現と役割の検討(Group78 子宮頸部悪性腫瘍9,一般演題,第61回日本産科婦人科学会学術講演会)
- DP-120-3 大腸癌肝転移症例におけるEMMPRIN, MMP-9, TypeIV collagenの発現(第107回日本外科学会定期学術集会)
- SF-054-1 膵癌における血行性転移の新たな治療戦略 : keratinocyte growth factor(KGF)/KGF receptor(KGFR)pathwayの役割の解析と制御(第107回日本外科会定期学術集会)
- P1-112 子宮内膜癌におけるKGF (Keratinocyte growth factor)およびKGF receptor (KGFR)の発現とその役割(Group10 子宮体部腫瘍3,一般演題,第59回日本産科婦人科学会学術講演会)
- ラットアルギニン誘発急性膵炎におけるネスチン発現細胞の検討
- ヒト膵癌におけるKGF,KGFRの発現とVEGFを介した静脈侵襲への関与
- ヒト膵癌組織におけるKGFR発現と臨床病理学的意義(膵臓10, 第60回日本消化器外科学会総会)
- 大腸癌肝転移症例におけるEMMPRIN (E), MMP-9 (M-9), IV型コラーゲン (IVc) の発現(第105回日本外科学会定期学術集会)
- 大腸癌リンパ節微小転移の生物学的意義
- PP-236 膵癌の転移浸潤形態の生物学的特性:VEGF発現及び増殖能に関する実験的検討
- P2-12 大腸癌組織におけるカテプシンBの局在とカテプシン B mRNAの発現の検討(第47回日本消化器外科学会総会)
- Use of electron microscopic evaluation for the diagnosis of adrenal cortical carcinoma in fine needle aspiration cytology : a case report and review of the literature
- The protective effect of hepatocyte growth-promoting factor (pHGF) against carbon tetrachioride-induced acute liver injury in rats: an ultrastructural study
- Solitary fibrous tumor of the pleura: report of a case with immunohistochemical and ultrastructural study
- A case report of renal cell tumor in a 45-year-old female mimicking lower portion nephrogenesis
- Thyroid papillary carcinoma arising in ectopic thyroid tissue within a branchial cleft cyst
- Effect of morpholino antisense oligonucleotide against lumican mRNA in human embryonic kidney (HEK) 293 cells
- Interleukin-8, Cyclo-oxygenase-2, and Trefoil Factor Family 1 Gene Expression and Their Association with Helicobacter pylori Infection in the Remnant Stomach
- Immunohistochemical and Morphometric Evaluations of Coronary Atherosclerotic Plaques Associated with Myocardial Infarction and Diabetes Mellitus
- Expression of Cathepsin B and Cystatin C in Human Breast Cancer
- Expression and Roles of Heat Shock Proteins in Human Breast Cancer
- Intravenous leiomyomatosis of the uterus with multiple pulmonary metastases associated with large bullae-like cyst formation
- Ossifying fibromyxoid tumor of soft parts : Clinicopathologic, immunohistochemical and ultrastructural study of four cases
- Gastrointestinal autonomic nerve tumors : Immunohistochemical and ultrastructural studies in cases of gastrointestinal stromal tumor
- Basic FGF and Ki-67 proteins useful for immunohistological diagnostic evaluations in malignant solitary fibrous tumor
- Expression of keratinocyte growth factor receptor (KGFR/FGFR2 IIIb) in vascular smooth muscle cells
- Immunohistochemical localization of endothelial cell markers in solitary fibrous tumor
- Expression of lumican in human colorectal cancer cells
- P4-46 Short and Long-Period Hyperglycemia Induce Different Reaction of ERK1/2 in Rat Heart
- P4-45 Aging Induced Failure of Myocardial ERK1/2 During Ischemia-Reperfusion via Intracellular Glycanation
- Long-term Hyperglycemia Reduced Myocardial ERK1/2 Phosphorylation is Directly Related with ERK1/2 Glycation in STZ-treated Rats(THE SIXTH JAPAN-CHINA JOINT SEMINAR ON HISTOCHEMISTRY AND CYTOCHEMISTRY)
- A-42 Effects of extracellular matrix on lumican expression and glycosylation in rat aortic smooth muscle cells in vitro
- Immunohistochemical localization of mitogen-activated protein kinase (MAPK) family and morphological changes in rat heart after ischemiareperfusion injury
- Ultrastructural changes and immunohistochemical localization of advanced glycation end products in the heart of streptozotocin-treated Mongolian gerbils
- Ultrastructural study of the mechanism of perineural extension in pancreatic cancer
- Ultrastructural changes and localization of nitric oxide synthase in rat lung induced by endotoxin administration
- Differential expression of hepatocyte growth factor and its receptor (c-Met) in a rat artificial anus model
- Expression of Basic Fibroblast Growth Factor, Epidermal Growth Factor, and Their Receptors in Castrated and Testosterone Injected Rat Prostates
- Process of Basement Membrane Re-formation After Intimal Denudation
- FINE STRUCTURAL STUDY OF Mg-ATPase AND ALKALINE PHOSPHATASE ACTIVITIES IN THE BLOOD-BRAIN BARRIER OF ISCHEMIC RATS
- Complete response of a patient with advanced gastric cancer, showing Epstein-Barr virus infection, on preoperative chemotherapy with S-1 and cisplatin
- Expression and Localization of Lumican in the Ischemic and Reperfused Rat Heart
- EXPRESSION OF TYPE IV PROCOLLAGEN AND PROLYL 4-HYDROXYLASE mRNA IN CARBON TETRACHLORIDE-INDUCED LIVER FIBROSIS STUDIED BY IN SITU HYBRIDIZATION
- Localization of Procollagen mRNAs and Prolyl 4-hydroxylase mRNA in Liver Fibrosis by ___- ___- Hybridization
- Localization of α1(III)procollagen mRNA on liver fibrosis by in situ hybridization
- IMMUNOHISTOCHEMICAL LOCALIZATION OF Na^+, K^+-ATPase IN HUMAN LIVER
- Immunohistochemical localization of Na^+, K^+ -ATPase of human and rat.
- HISTOCHEMICAL STUDY OF BILE DUCTULAR CELLS IN CHOLESTASIS
- Immunohistochemical and ultrastructural studies of basal cells, Clara cells and bronchiolar cuboidal cells in normal human airways
- Immunohistochemical and ultrastructural studies of basal cells, Clara cells and bronchiolar cuboidal cells in normal human airways
- Histochemical Characterization of Mast Cell Granules
- Phenolic Glycolipid-1 in tissue of Mycobacterium ulcerans infected patients
- Malignant Melanoma of the Buttock Presenting as a Buruli Ulcer
- The neurological disturbance of Buruli Ulcer compared to that of leprosy
- FURTHER CHARACTERIZATION OF THE CLINICO-PATHOLOGICAL FEATURES OF BURULI ULCER
- Brief Survey of Leprosy Situation in Congo : Sero-Epidemiologic Profile in Correlation with Some Emerging Viral Infections
- Overexpression of keratinocyte growth factor in cancer cells and enterochromaffin cells in human colorectal cancer
- The expression and localization of β-endorphin and μ, δ-opioid receptors in synovial tissues in patient with rheumatoid arthritis and osteoarthritis
- Ultrastructural localization of alkaline phosphatase and Ca^-ATPase in mesenchymal cell on bone differentiation
- Nitric Oxide Production and Energy State in the Heart after Endotoxin Administration
- Histochemical localization of Ca^-ATPase in endotoxin administered rat liver
- Hereditary protein S deficiency associated with rheumatoid arthritis: a case report of pulmonary embolism after total hip arthroplasty
- Clinico-neuropathological study of incontinentia pigmenti achromians-an autopsy case
- Expression of PCNA, Basic Fibroblast Growth Factor, FGF-receptor and Vascular Endothelial Growth Factor in Adenomas and Carcinomas of Human Colon
- Role of F4/80^+Mac-1^ adherent non-parenchymal liver cells in concanavalin A-induced hepatic injury in mice
- 博慈会オープンセサミ賞 膵癌細胞の3次元スフェロイド培養における形態構造と細胞骨格の変化 (平成23年度助成研究論文)
- Follicular dendritic cell sarcoma with microtubuloreticular structure and virus-like particle production in vitro
- Epithelial and Stromal Changes after Castration and Testosterone Treatment in Rat Prostate
- Morphological and cytoskeletal changes of pancreatic cancer cells in three-dimensional spheroidal culture
- Experimental Study on a Prism-External-Cavity Semiconductor Laser with Dispersion Feedback
- PS-105-1 膵癌における各腫瘍血管マーカーと臨床病理学的因子との関連(PS-105 ポスターセッション(105)膵臓:基礎-2,第111回日本外科学会定期学術集会)
- Time Course of Expression and Localization of Heat Shock Protein 72 in the Ischemic and Reperfused Rat Heart
- PD-4-8 Nestinによる膵癌腫瘍新生血管増殖制御と新たな分子標的治療の可能性(PD-4 パネルディスカッション(4)癌分子標的治療up to date,第112回日本外科学会定期学術集会)
- An Ultrastructural Study of the Angiopathy induced in SHR (I)
- Differential Distribution of ecNOS and iNOS mRNA in Rat Heart after Endotoxin Administration.