クロム酸ナトリウム投与時のマウス腎に出現するシスタチン様物質

概要

論文の詳細を見る
Cystatins, which belong to a superfamily of cystatin, are present in human saliva as well as in the kidneys of renal patients. The kidneys, salivary glands, lacrimal glands, various tissue extracts, whole saliva and urine of mice with kidney disorders induced by sodium chromate treatment were examined for the presence of mouse salivary cystatins (MSC). Sodium chromate (2mg) was subcutaneously administered at four places in a dorsal part. MSC A and MSC-B and their antibodies were previously purified, prepared and reported by the first author^<16)>. Here the Lowry method for protein concentration, immunoblotting method and immunohistological methods such as ABC and immunofluorescence methods were used. MSC-A and MSC-B-like substances were present in urine and uriniferous tubules of mice administered sodium chromate. However, no marked changes were observed in the localization or concentration of MSC-A and MSC-B in the parotid, submandibular and lacrimal glands of mice administered sodium chromate. MSC-A and MSC-B, derived from the salivary glands, may inhibit cathepsin L in the kidneys where it may be involved in inflammatory responses.
福岡歯科大学学会の論文
1995-09-30