血管内皮細胞と細胞外マトリックス蛋白との相互関係 : 特に動脈硬化症ならびに血管新生を中心に(<特集>動脈硬化と細胞外マトリックス)

概要

論文の詳細を見る
Vascular endothelial cell plays a critical role in the preservation of normal vascular wall integrity and function. The endothelial cells not only provide a structural barrier between the circulation and surrounding tissue, but also secret mediators that prevent arterial vasomotion, thrombosis or neointimal proliferation. The normal endothelial cell function is partly regulated by the interaction with extracellular matrix (ECM) through integrins, cell surface receptors. Endothelial cells also play a central role in angiogenesis, the formation of new capillaries from preexisting blood vessels. During the process of angiogenesis, endothelial cells migrate, proliferate, and differentiate into capillary-like tubes. These processes are highly regulated not only by specific cytokine/receptor combinations, but also by ECM. This review focuses on the involvement of ECM in vascular endothelial cell functions and discusses the current knowledge about the potential role of ECM and endothelial cell interaction in the pathogenesis of atherosclerosis and the process of angiogenesis.
日本結合組織学会の論文
2002-12-25