歯周病患者の白血球のNitroblue tetrazolium還元試験の検討

概要

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Sixty patients with various degrees of periodontal disease were studied to determine whether measurement of the reduction of nitroblue tetrazolium dye (NBT) by polymorphonuclear neutrophils was of value in diagnosis in periodontal disease The following results were obtained. 1. A significant correlation was found between the percentage of NBT-positive cells and the salivary leukocyte count which is the parameter of periodontal inflammation (p<0.01). 2. The percentage of NBT-positive cells, however, did not show a signifcant correlation with Dunning and Leach's Gingival-Bone count. 3. The rate of NBT-positive cells in blood from the gingiva was higher than that in venous blood. It was testified that this was due to contamination of blood with dental plaque when blood was taken from the gingiva. The neutrophils were stimulated both by the phagocytosis of oral microorganisms and by endotoxin.
特定非営利活動法人日本歯周病学会の論文
1976-12-28