競争馬における dopoing drugs の薬理学的研究 : III. Caffeine

概要

論文の詳細を見る
Caffeine was studied experimentally for influence upon the running performanceof race horses. Three Thoroughbred horses, 6 years old castrated and weighing about420--500 kg, were injected subcutaneously with a single dose of 2.5 and 5.0 g (usualdose)) per animal of caffeine and sodium benzoate, respectively, in a 20% solution.They were subjected to an exercise started about l hour after the injection. The ex-perimental procedure used was the same as mentioned in the previous reportl), exceptthe standard lap times, which were as follows: 50sec./round (ll4m/min.) at walk,25sec./round (228m/min.) at trot, and 17sec./round (335m/ruin.) at canter (Fig.1).In addition, caffeine was also examined for influence upon electrocardiogram (ECG),respiration, and behavior in stabled horses at rest. The results obtained are summarizedas follows.l. Caffeine enhanced the running performance; that is, a shortened lap time wasrecorded frequently, particularly in exercise at canter (Fig. 3). Furthermore, it wasdifficult for horse No. 2 injected with 5.0 g to continue running at canter, because thediameter of the track was not long enough to run at an enhanced speed.2. To horse No.2 injected with 2,5 g, consecutive second-degree A-V blocks occa-sionally followed by a S-A block occurred three times intermittently immediately afterthe exercise (Fig. 4). This kind of successive arrhythmias never occurred to stabledhorses at rest even after administration with 5.0 g.3. Cafleine increased the heart rate during the exercise, particularly in exercise atcanter, and delayed the recovery of the heart rate (Figs. 5 and 6).4. Caffeine brought about no clear changes in stepping frequency during theexercise or in breathing rate during the recovery.5. Although a dose of 2.5 g induced no changes in ECG, heart rate, breathing rate,or behavior in any resting horse, it exerted definite influences upon the running perform-ance, the heart rate during and after the exercise, and ECGS immediatery after theCX(TCISCI.6. zran.s-m-Oxocamphorl) exerted only a
社団法人日本獣医学会の論文
1972-06-25

競争馬における dopoing drugs の薬理学的研究 : III. Caffeine

スポンサーリンク

概要

著者

関連論文

スポンサーリンク