広東住血線虫感染家兎ならびにラットにおけるレアギン様抗体の産生について

概要

論文の詳細を見る
Angiostrongylus cantonensis-infected rabbits and rats were monitered for the productions of reaginic and indirect hemagglutinating (IHA) antibodies. Rabbit reaginic antibody detected by 72 hour homologous passive cutaneous anaphylaxis (PCA) was first demonstrated in sera of rabbits infected with 230 infective larvae 9 weeks after primary infection and persisted at very low titers for considerable duration. When such rabbits were reinfected with 600-820 larvae on Day 36, the reaginic antibody occurred much earlier, i.e., as early as 6 weeks after primary infection. The secondary and tertiary infections markedly boosted the PCA titers which gradually declined thereafter. Rabbit reaginic antibody was heat resistant but other physico-chemical properties were analogous to human IgE. No substantial IHA antibody productions were observed in sera of the infected Tabbits. A peak reaginic antibody response in rats was observed 5 weeks after primary infection. However, the reaginic antibody production in rats was only transient and no anamnestic response was induced by reinfection. In rats, IHA antibody was first detected in sera as early as 6 weeks postinfection and persistently observed throughout 6 to 18 weeks postinfection. Reinfections significantly boosted the IHA titers in some rats but not in the others.
社団法人日本獣医学会の論文
1976-02-25