B212 微小血管壁に粘着している白血球に働く力の評価

概要

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In cell-biological research, two-dimensional flow chambers are used extensively to study cell-substrate adhesion, so that it is of great interest whether the results obtained in the 2-D flow chambers can be directly applicable to the actual 3-D flow in vessels. This study is aimed to examine whether the drag force and the torque acting on an adherent cell in a vessel are equal to those on the cell adhered to the planar wall of a 2-D flow chamber, if the shear rate at the wall is identical. The forces acting on a cell adhered to a vessel wall were computed by a numerical simulation, and compared to the previous results for spherical particles in 2-D flow chambers. It was found that the drag force acting on an adherent particle in the vessel flow is significantly larger than that in the 2-D chamber flow, mainly due to the difference in the pressure acting on the particle. This tendency is more enhanced in smaller vessels and/or when multiple adherent particles are present.
日本流体力学会の論文
2000-07-25