1514 微小血管内の白血球運動 : 浮遊白血球表面の応力分布

概要

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The distributions of the stresses acting on the surface of a leukocyte freely floating in non-uniform microvessels are numerically analyzed. For simplicity, leukocytes are modeled as rigid spherical particles and the model cell is suspended in an incompressible Newtonian fluid flowing through a circular cylinder whose wall has a protrusion with a sinusoidal shape into the lumen. The effect of the presence of a layer of bound or adsorbed macromolecules at interior surfaces of blood vessels, known as the endothelial surface layer (ESL), on the stress distribution acting on the floating cell is also examined using a porous media-like model. It is shown that leukocytes freely floating in microvessels experience variations of pressure and shear stress on their surfaces exerted by the fluid flow, when they translate accompanied by the rotation. The amplitude of the stress variation is found to be largely enhanced by the presence of the protrusion of the vessel wall as well as the ESL.
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