マウス歯根膜の加齢的変化 : 形態学的および蛍光抗体法による観察

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Morphological and immunofluorescent studies of age-dependent changes of the periodontal ligaments were performed in the lower first molars of mice ranging ina age from 1 week to 80 weelcs after birth. The alveolar bone which was completed by 20 weeks, was gradually decreased in amount and its surface bordered upon the periodouatal ligament became irregular resulting in wavy appearance after 20 weeks postpartum. A space which was occupied by the periodontal ligament decreased in width with aging, probably because of deposition of newly formed cementum on the surface of the root. In addition, cells in the periodontal ligaments also became decreased in number with aging. Moreover, a interstitial space of eacla collagen fiber bundles enlarged. The type I and type III collagens, and fibronectin were distributed in close association with the periodontal fibers. The immunoreactive products of the type III collagen was intensity deposited on the fiber bundles of periodontal ligament being close to the alveolar bone of miceranging in age from 2 to 20 weeks after birth. This fact indicates that an active synthesis of type III collagen occured in this region. In mice of after 30 weeks postpartum, the junctional epithelium proliferated and migrated down to the apical side along the cementum resulting in deepening gingival pocket. The fibronectin was strongly stained on the external basement membrane of migrating junctional epithelium. This finding suggests that the fibronectin played an important role in the proliferation and migration of the junctional epithelium.
日本補綴歯科学会の論文
1991-08-01

マウス歯根膜の加齢的変化 : 形態学的および蛍光抗体法による観察

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