粘土鉱物系抗菌抗黴剤に関する研究(9) : Ag[2-(4-チアゾリル)ベンズイミダゾール]_2錯体と複数の第4級アンモニウムを坦持したモンモリロナイトの諸特性

概要

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Montmorillonite intercalated with silver chelate of 2-(4-thiazolyl)-benzimidazole and quaternary ammonium cations (n-dodecyltrimethylammonium and hexadecylpyridinium) that has antibacterial and antifungal activities was prepared by cation exchange reaction (DHTAM). The resulting material was subjected to antibacterial and antifungal activities examination and its structure was observed before and after heating up to 400℃. Minimum inhibitory concentration tests showed that the sample has strong antibacterial and antifungal activities except with that of fungi of Aspergillus niger. Lost of antibacterial activities after heating at 250℃ occurred in only quaternary ammonium cations intercalated montmorillonite, but the DHTAM was stable up to 200℃ and eventually decomposed at 400℃ resulting to the development of fine silver particles having significant antibacterial activities against bacteria of Escherichia coli and Staphylococcus aureus. The diameter of silver particles was 20-40nm, and did not change with increasing temperature. Three cations intercalated in montmorillonite showed simultaneously their characteristic individual activity, however, no synergetic activity was observed in each intercalant. By using the present technique, it is possible to prepare more systematically an agent with desired antimicrobial and antifungal activities.
日本粘土学会の論文
1997-10-31