The in Vivo Effect of Cordyceps sinensis Mycelium on Plasma Corticosterone Level in Male Mouse(Biopharmacy)

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概要

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• Cordyceps sinensis (CS), an Ascomycetes fungus parasitic to Lepidoptera larvae, has been traditionally used as nutritious food for the enhancement in immuno-modulation in Chinese society for a long time. Previous report has demonstrated the CS water extract stimulates in vitro corticosterone production in rat primary adrenal cells. In the present studies, we determined the in vivo effects of CS and its fractions on plasma corticosterone production in mouse. Different concentrations of CS and CS fractions dissolved in water (0.02 and 0.2mg/g body weight) were fed to immature and mature mice from 1, 3 or 7d. The plasma levels of corticosterone were determined by radioimmunoassay (RIA), and the weight of adrenal gland and body weight were also evaluated. Results illustrated that plasma corticosterone levels were significantly induced by F2 at 0.02mg/g body weight with 7d feeding in immature mice, and by CS at 0.02mg/g body weight with 3d feeding and F3 at 0.02mg/g body weight for 7d feeding in mature mice, respectively (p<0.05). There were no differences of adrenal gland weight except there was significant stimulation by CS at 0.2mg/g body weight with 3d feeding in mature mice (p<0.05) and there were significant inhibitions by both dosages of F3 for 3d feeding in immature mice and F2 for 7d feeding in mature mice (p<0.05), respectively. Concerning body weight, the stimulatory effects were observed with CS feeding at 0.2mg/g body weight for 7d and F3 feeding at 0.02mg/g body weight for 3 and 7d in mature mice. Whereas, the inhibitory effect were observed in F2 feeding at 0.2mg/g body weight for 7d in immature mice and at both dosages for 7d in mature mice, respectively. Taken together, these studies illustrate that CS and its fractions stimulated mouse in vivo corticosterone production. However, CS and its fractions didn't have constant stimulatory or inhibitory effects on the weights of body and adrenal glands.

• 公益社団法人日本薬学会の論文
• 2005-09-01

著者

• TSENG Chi

  Department of Biological Science and Technology, National Chiao Tung University

• CHIEN Chi

  Department of Mechanical Engineering, National Sun Yat Sen University

• Chien Chi

  Department Of Cell Biology And Anatomy College Of Medicine National Cheng Kung University

• Chien Chi-hsien

  Department Of Anatomy College Of Medicine National Taiwan University 1 Section 1

• Tseng Chi

  Department Of Cell Biology And Anatomy College Of Medicine National Cheng Kung University

• Tseng Chi

  Department Of Biological Science And Technology National Chiao Tung University

• LEU Sew

  National Laboratory Animal Breeding and Research Center, National Science Council, Taipei, Taiwan, R

• KUO Yu

  Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University

• HUANG Bu

  Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University

• Leu Sew

  National Laboratory Animal Breeding And Research Center National Science Council Taipei Taiwan Repub

• Leu Sew-fen

  National Laboratory Animal Breeding And Research Center

• Huang Bu

  Department Of Cell Biology And Anatomy College Of Medicine National Cheng Kung University

• Kuo Yu

  Department Of Cell Biology And Anatomy College Of Medicine National Cheng Kung University

• Tseng Chi-Yu

  Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University

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