Contribution of glucuronic acid and sulfonic acid moieties during photocatalytic degradation of estrogen conjugates
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概要
- 論文の詳細を見る
Contribution of glucuronic acid and sulfonic acid moieties during the photocatalytic degradation of estrogen conjugates, one of the endocrine disrupting chemicals, has been investigated. Estrogens were subjected to photocatalytic degradation using titanium dioxide immobilized on glass beads as a catalyst, whose time courses were measured by HPLC or liquid chromatography (LC)/MS/(MS). Estradiol and estrone, which have an unconjugated phenolic hydroxy group at the C-3 position, were gradually degraded by UV irradiation and nearly disappeared within 6 hr. 3-Desoxyestradiol, which does not have a phenolic hydroxy group at C-3 position, was also degraded like estradiol. The corresponding 17- or 3-glucuronide was degraded faster than the respective genin, estradiol or estrone. The double conjugate, estriol 3-sulfate 16-glucuronide, was also easily degraded within 3 hr. On the other hand, the degradation of estrogen 3-sulfate did not start within 2.5 hr but the reaction was completed within 6 hr. These data showed that the glucuronic acid moiety on the estrogen skeleton and sulfonic acid moiety at phenolic hydroxy group play an important role for this degradation reaction.
- 公益社団法人日本薬学会の論文
- 2005-08-01
著者
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SHIMADA Kazutake
Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa Uni
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Mitamura Kuniko
Division Of Pharmaceutical Sciences Graduate School Of Natural Science And Technology Kanazawa Unive
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Shimada Kazutake
Division Of Pharmaceutical Sciences Graduate School Of Natural Science And Technology Kanazawa Unive
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Mitamura K
Division Of Pharmaceutical Sciences Graduate School Of Natural Science And Technology Kanazawa Unive
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Mizuguchi Tatsuhito
Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa Uni
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Shibayama Yujin
Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa Uni
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Shimada Kazutake
Division Of Pharmaceutical Sciences Graduate School Of Natural Science And Technology Kanazawa Unive
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Shibayama Yujin
Division Of Pharmaceutical Sciences Graduate School Of Natural Science And Technology Kanazawa Unive
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Shibayama Yujin
Division Of Pharmaceutical Sciences Graduate School Of Natural Science And Technology Kanazawa Unive
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Mizuguchi Tatsuhito
Division Of Pharmaceutical Sciences Graduate School Of Natural Science And Technology Kanazawa Unive
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