Alternative Procedure for Charged Derivatization to Enhance Detection Responses of Steroids in Electrospray Ionization-MS
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概要
- 論文の詳細を見る
A derivatization procedure has been examined to enhance the electrospray ionization (ESI)-MS detectabilities of steroids that charged derivatization is not suitable for. The derivatization procedure with 2-hydrazinopyridine or isonicotinoyl azide was very effective for the sensitive detection of di-oxosteroids or di-hydroxysteroids, respectively, and the detection limits of the resulting derivatives were as low as about 2 fmol. The derivatives also provided intense characteristic product ions in the MS-MS, which are expected to be usable for the selected reaction monitoring mode.
- 公益社団法人日本薬学会の論文
- 2007-04-01
著者
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HIGASHI Tatsuya
Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa Uni
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SHIMADA Kazutake
Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa Uni
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Hayashi Noriko
Division Of Pharmaceutical Sciences Graduate School Of Natural Science And Technology Kanazawa Unive
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NISHIO Tadashi
Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa Uni
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Higashi Tatsuya
金沢大学 自然科学研究科
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Higashi Tatsuya
Division Of Pharmaceutical Sciences Graduate School Of Natural Science And Technology Kanazawa Unive
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Shimada Kazutake
Division Of Pharmaceutical Sciences Graduate School Of Natural Science And Technology Kanazawa Unive
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Nishio Tadashi
Division Of Pharmaceutical Sciences Graduate School Of Natural Science And Technology Kanazawa Unive
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Higashi Tatsuya
静岡県立大学 薬学部
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SHIMADA Kazutake
Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University
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