In Vitro Glucuronidation of 25-Hydroxyvitamin D_3 and Its Pro-form
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概要
- 論文の詳細を見る
In vitro glucuronidation of 25-hydroxyvitamin D_3 and its pro-form has been investigated by means of HPLC with UV detection. Although both substrates gave 3- and 25-glucuronides in the presence of the ray liver microsomal fraction and uridine-5'-diphosphoglucuronic acid, 25-hydroxyvitamin D_3 and its pro-form yielded 3- and 25-glucuronide as the main product, respectively. The latter glucuronide is the one in which the tert-hydroxy group is conjugated. Each glucuronide was identified by its chromatographic behavior in comparison with an authentic sample and data obtained from liquid chromatography/mass spectrometry (LC/MS) using atmospheric pressure chemical ionization.
- 公益社団法人日本薬学会の論文
- 1997-06-15
著者
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Mitamura Kuniko
Faculty of Pharmaceutical Sciences, Kinki University
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SHIMADA Kazutake
Faculty of Pharmaceutical Sciences, Kanazawa University
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Mitamura Kuniko
Faculty Of Pharmaceutical Sciences Kanazawa University
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Shimada Kazutake
Faculty Of Pharmaceutical Sciences Kanazawa University
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Mitamura K
Division Of Pharmaceutical Sciences Graduate School Of Natural Science And Technology Kanazawa Unive
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Shimada Kazutake
Div. Of Pharmaceutical Sciences Graduate School Of Natural Sci. And Technol. Kanazawa Univ.
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KAMEZAWA Yuko
Faculty of Pharmaceutical Sciences, Kanazawa University
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Kamezawa Yuko
Faculty Of Pharmaceutical Sciences Kanazawa University
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